Results 51 to 60 of about 32,756 (214)

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method [PDF]

, 2015
Background: Montelukast (MT) is a leukotriene D4 antagonist. It is an effective and safe medicine for the prophylaxis and treatment of chronic asthma. It is also used to prevent acute exercise-induced bronchoconstriction and as a symptomatic relief of ...
Abualhasan, Murad N, Bustami, Rana, Ghazal, Nadia, Mousa, Ayman, Watson, David G, Zaid, Abdel Naser   +5 more
core   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Analysis of chromameter results obtained from corticosteroid-induced skin blanching assay: comparison of visual and chromameter data [PDF]

, 1999
In a Guidance document, the American FDA recommends the use of a Minolta chromameter rather than the human eye for the quantitative assessment of the pharmacodynamic blanching response produced by topical application of corticosteroids.
Haigh, J M, Schwarb, F P, Smith, E W, Surber, C   +3 more
core   +2 more sources

Relative Bioavailability, Food Effect, and Bioequivalence Studies to Assess a New Zanubrutinib 160‐mg Tablet: Results From 2 Phase 1 Studies in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Zanubrutinib is a next‐generation Bruton tyrosine kinase inhibitor approved for treating B‐cell malignancies. Two phase 1 studies evaluated a new 160‐mg zanubrutinib tablet versus 80‐mg capsules. In study BGB‐3111‐115 (n = 43), a randomized 3‐period crossover trial, relative bioavailability and food effects were assessed.
Bilal Tariq, Chester Lin, Vaibhav Mundra, Yang Gao, Dan Zhang, Ying C. Ou   +5 more
wiley   +1 more source

The impact of the reference price system on the pharmaceutical market: A theoretical approach [PDF]

This article analyses the impact of the reference price system on the price-setting strategies of the pharmaceutical firms and on the level of generic usage.
Anna Merino
core  

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre‐Filled Pen Versus Pre‐Filled Syringe in Healthy Participants

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Garadacimab is a novel, fully human, anti‐activated factor XII monoclonal antibody approved for long‐term prophylaxis of patients with hereditary angioedema. This open‐label, parallel‐group, Phase 1, single‐center, bridging study in healthy adults (18–55 years of age) characterized the pharmacokinetics and safety of a single 200 mg ...
Fiona Glassman, John‐Philip Lawo, Mihai Alexandru Bica, Anthony Roberts, David Kormann, Ligia Chialda, Soeren Miethke, Iwona Dziadowiec, Stephen Caltabiano, Thomas Puchalski   +9 more
wiley   +1 more source

Testing for Multivariate Equivalence with Random Quadratic Forms [PDF]

, 2005
Multivariate equivalence testing becomes necessary whenever the similarity rather than a difference between several treatment groups with multiple endpoints has to be shown.
Weißbach, Rafael
core   +1 more source

Breast Cancer Vaccine: Are We There Yet? [PDF]

, 2012
In lieu of an abstract, here is the article\u27s first paragraph: Breast cancer is the most fatal form of cancer for female population worldwide. National Cancer Institute (NCI) estimates 226,870 females and 2,190 males to be diagnosed with breast cancer
Chablani, Lipika
core   +2 more sources

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source