Results 61 to 70 of about 16,124 (183)

Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions

, 2023
Wanjun Bai,1 Haojing Song,1 Yiting Hu,1 Xueyuan Zhang,2 Xiaoru Wang,3 Caihui Guo,1 Bo Qiu,1 Zhanjun Dong1 1Department of Pharmacy, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Shanghai Innovstone Therapeutics Limited ...
Hu Y, Zhang X, Dong Z, Qiu B, Wang X, Guo C, Song H, Bai W   +7 more
core  

The Emerging Threat of Antibiotic Residues in the Aquatic Environments of East Africa: A Systematic Review

Environmental Health Insights
Background: Antibiotic contamination of aquatic ecosystems, driven by poor waste management, is a critical public and environmental health concern in East Africa, though comprehensive regional data remain limited.
Duresa Dedefo, Gemmechu Hasen, Belachew Umeta, Desta Assefa, Yesuneh Tefera Mekasha, Simon Genet, Daniel Legese Achalu, Habtewold D. Waktola, Dereje Kebebe, Sileshi Belew, Sultan Suleman   +10 more
doaj   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

First‐In‐Human Study of Mirogabalin (BM2216) Sustained‐Release Tablets: Safety, Tolerability, Pharmacokinetics, Food Effect and Dose Proportionality With Comparison to Mirogabalin Besylate in Healthy Participants

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To characterise the pharmacokinetics (PKs) and safety of BM2216 sustained‐release (SR) tablets after single‐dose oral administration under fasted/fed conditions in healthy participants, assess the effect of food and dose proportionality, and compare the single and multiple‐dose PK of BM2216 SR tablets with mirogabalin besylate tablets to ...
Peiyang Song, Hongtao Zhao, Mingxue Zhu, Lei Wan, Yuan Chen, Zhongping Li, Chengyong Tang   +6 more
wiley   +1 more source

Bioequivalence Evaluation of two formulations of lamotrigine tablets in healthy volunteers

, 2012
: Lamotrigine is a phenyltriazine used in the treatment of epilepsy and bipolar disorder type I. The purpose of this study was to compare the bioavailability in healthy Colombian volunteers of two brands of lamotrigine 100 mg tablets: a new generic ...
Restrepo Garay, Margarita María, Archbold, Rosendo, Montoya Beltrán, Blanca Cecilia, Ruiz Correa, Adriana María, Cuesta González, Fanny, Holguín Martínez, Gloria, Parra, Sergio, Peña Acevedo, Lina   +7 more
core   +1 more source

Nanocarriers based therapy and diagnosis of brain diseases: cross the blood-brain barrier

Science and Technology of Advanced Materials
The blood-brain barrier (BBB) is the protective interface that isolates the central nervous system from circulating blood, which restricts approximately 98% of small molecule drugs and nearly all large molecules from entering the brain.
Lijun An, Jinwei Zhang, Xiaobo Wang, Yuanyuan Ge, Kunhui Sun, Junlin Dong, Ping Wang, Wei Li, Meifang Li, Xuelei Hu, Bing Wang, Xie-An Yu   +11 more
doaj   +1 more source

Generic-reference and generic-generic bioequivalence of forty-two, randomly-selected, on-market generic products of fourteen immediate-release oral drugs

BMC Pharmacology and Toxicology, 2017
Background The extents of generic-reference and generic-generic average bioequivalence and intra-subject variation of on-market drug products have not been prospectively studied on a large scale.
Muhammad M. Hammami, Sophia J. S. De Padua, Rajaa Hussein, Eman Al Gaai, Nesrine A. Khodr, Reem Al-Swayeh, Syed N. Alvi, Nada Binhashim   +7 more
doaj   +1 more source

Evaluation of an ABO antibody immunoadsorption column for reduction of anti‐A and anti‐B isoagglutinin titers in group O platelet units

Transfusion, EarlyView.
Abstract Background Clinical guidelines recommend transfusing ABO‐identical platelets where possible. However, the short shelf life of platelets (5–7 days) and stock availability mean ABO‐nonidentical platelet transfusions are sometimes unavoidable. Minor ABO‐incompatible platelet transfusions carry a risk of hemolysis due to donor anti‐A/B antibodies,
Melanie J. Robbins, Susan Proffitt, Gillian Eastwood, Sian Huish, Kurt Nilsson, Rebecca Cardigan   +5 more
wiley   +1 more source

ESTABLISHING POPULATION AND INDIVIDUAL BIOEQUIVALENCE CONFIDENCE INTERVALS [PDF]

, 2000
Average bioequivalence is used to assess pharmacokinetic properties of proposed generic drug before they are marketed. The limitations of average bioequivalence have led the U.S.
Yu, Feng, Stevens, Gary R., Linda J. Young, Young, Linda J., Gary R. Stevens, Feng Yu   +5 more
core   +1 more source

Bioequivalence trials for the approval of generic drugs in Saudi Arabia: a descriptive analysis of design aspects

BMC Medical Research Methodology
Background This retrospective analysis aimed to comprehensively review the design and regulatory aspects of bioequivalence trials submitted to the Saudi Food and Drug Authority (SFDA) since 2017.
Turki A. Althunian, Bader R. Alzenaidy, Raseel A. Alroba, Ohoud A. Almadani, Fahad A. Alqahtani, Albatool A. Binajlan, Amal I. Almousa, Deema K. Alamr, Malak S. Al-Mofada, Nora Y. Alsaqer, Hessa A. Alarfaj, Abdulmohsen A. Bahlewa, Mohammed A. Alharbi, Ali M. Alhomaidan, Abdulaziz A. Alsuwyeh, Abdulmohsen A. Alsaleh   +15 more
doaj   +1 more source