Results 51 to 60 of about 16,124 (183)

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Pharmacokinetics and Safety of 1 mg Oral Minoxidil Tablets in Healthy Female Volunteers: A Phase I Randomized Crossover Clinical Trial

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Topical minoxidil is a first‐line treatment for female androgenetic alopecia (FAGA); however, its twice‐daily application, potential for scalp irritation and impact on hair texture can compromise adherence. Although low‐dose oral minoxidil has emerged as a promising alternative, standardized formulations with well‐characterized ...
Dolores Ochoa Mazarro, Ignacio Galicia, Ana López‐Ballesteros   +2 more
wiley   +1 more source

Fed and Fasting Bioequivalence Study for Two Formulations of Bosentan 125 Mg Tablets in Healthy Colombian People

, 2015
6 páginasThis is a pharmacokinetic study of two formulations containing Bosentan 125 mg, in order to compare the bioavailability between the Test product (Bosentan produced by Tecnoquímicas S.A.
Bustamante C., Villarraga EA., Vargas M.
core   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

The implementation of the bioequivalence certification policy in Chile: An analysis of market authorization data.

PLoS ONE, 2019
BackgroundAffordability is a key barrier to access to medicines. Generic medicines policies can address this barrier and promote access. Successful uptake of generic medicines depends, in part, on ensuring that these products are interchangeable with ...
Warren A Kaplan, Jorge Cárdenas, Cristián Mansilla, Tatiana Tobar, Veronika J Wirtz   +4 more
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core   +1 more source

When is the bait worth the risk? A mechanistic model of a compensatory ecological trap in seabirds

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ecological traps occur when organisms preferentially select habitats that reduce fitness. In seabird–fishery systems, fishery‐derived trophic subsidies can increase foraging success, reinforce habitat preference and indirectly enhance reproductive output or recruitment,
Cristóbal Anguita, Alejandro Simeone, Cristián F. Estades   +2 more
wiley   +1 more source

Testing for Multivariate Equivalence with Random Quadratic Forms [PDF]

Multivariate equivalence testing becomes necessary whenever the similarity rather than a difference between several treatment groups with multiple endpoints has to be shown.
Weißbach, Rafael
core