Results 51 to 60 of about 26,646 (226)

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Semiparametric Bayesian Modeling of Multivariate Average Bioequivalence [PDF]

, 2006
Bioequivalence trials are usually conducted to compare two or more formulations of a drug. Simultaneous assessment of bioequivalence on multiple endpoints is called multivariate bioequivalence.
Ghosh, Pulak, Dr., Gonen, Mithat
core   +1 more source

Nutraceutical-based integrative medicine: adopting a mediterranean diet pyramid for attaining healthy ageing in veterans with disabilities [PDF]

, 2018
Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans.
Aiello, Paola, Buccolieri, Cosimo, Catasta, Giovina, Ciccotti, Mario, Lista, Florigio, Palmery, Maura, Peluso, Ilaria, Raguzzini, Anna, Reggi, Raffaella, Sciarra, Tommaso   +9 more
core   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Generative Neural Networks for Addressing the Bioequivalence of Highly Variable Drugs

Algorithms
Bioequivalence assessment of highly variable drugs (HVDs) remains a significant challenge, as the application of scaled approaches requires replicate designs, complex statistical analyses, and varies between regulatory authorities (e.g., FDA and EMA ...
Anastasios Nikolopoulos, Vangelis D. Karalis   +1 more
doaj   +1 more source

Elaboration of technology and comparative research of pellets of tamsulosin the modified liberation

Бюллетень сибирской медицины, 2011
The work purpose consisted in elaboration of technology of reception pellets of tamsulosin with the modified liberation, and also an estimation of their comparative bioequivalence with a comparison preparation.
Ye. V. Blynskaya, N. A. Uvarov, Ye. Ye. Lazareva, V. K. Alexeyev   +3 more
doaj   +1 more source

Efficacy, Safety and PK of Once‐Daily Oral Semaglutide 25 mg for Obesity With and Without Type 2 Diabetes in Comparison With Subcutaneous Semaglutide 2.4 mg: A Model‐Informed Drug Development Approach

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide has previously been approved for weight management and cardiovascular disease as a subcutaneous formulation, and more recently also as an oral formulation. However, there is limited information across oral dose levels, and there are no studies for the 25 mg dose in people with obesity and type 2 diabetes (T2D).
Rune Viig Overgaard, Oscar Birkhan, Naveen Rathor, Thomas Sparsø, Anders Strathe, Sean Wharton, Domenica Rubino   +6 more
wiley   +1 more source

Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Klein, Sandra, Taupitz, Thomas
core  

Coherent frequentism [PDF]

, 2009
By representing the range of fair betting odds according to a pair of confidence set estimators, dual probability measures on parameter space called frequentist posteriors secure the coherence of subjective inference without any prior distribution.
Datta G. S., David R. Bickel, Fisher R. A., Fisher R. A., Gleser L. J., Hacking I., Hannig J., Kaplan M., Kyburg H. E. J., Molchanov I., Paris J. B., Pawitan Y., Smith C. A. B., Walley P., Welch B. L., Wilkinson G. N., Williamson J.   +16 more
core   +1 more source

Pharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants With Obesity or Overweight

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the bioequivalence of orally administered orforglipron tablets and capsules in participants with obesity or overweight who were otherwise healthy. Materials and Methods This phase 1, multicenter, open‐label, multiple‐dose, dose‐escalation study was conducted in 429 healthy adults.
Xiaosu Ma, Ying Grace Li, Sohini Raha, David C. Sperry, David E. Coutant, Shobha Bhattachar   +5 more
wiley   +1 more source