Results 261 to 270 of about 662,832 (342)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Biofilm formation by the global outbreak strain of Mycobacterium chimaera results in significantly reduced efficacy of standard disinfectants. [PDF]

BMC Microbiol
Oschmann AM, Konrat K, Schaudinn C, Sohl G, Wagner D, Lewin A, Arvand M.   +6 more
europepmc   +1 more source

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, EarlyView.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

Ultrasound-activated and P-selectin-targeted liposomes overcome biofilm barriers for surgical site infections therapy. [PDF]

J Nanobiotechnology
Liu X, Huang Z, Hu C, Zhao Y, Pan H, Wu Y, Fang X, Chen J, Liu Y, Wang G, Huang P.   +10 more
europepmc   +1 more source

Biosynthesis of H2S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species

Advanced Science, EarlyView.
Discover how Gram‐negative bacteria develop resistance to reactive oxygen species, and how scientists aim to overcome this challenge. Abstract Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and ...
Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M. C. Cheung, Kelvin Wai Kwok Yeung   +9 more
wiley   +1 more source

Mechano‐Bactericidal Surfaces Achieved by Epitaxial Growth of Metal–Organic Frameworks

Advanced Science, EarlyView.
Mechano‐bactericidal surfaces based on metal–organic frameworks (MOFs) are designed using a MOF‐on‐MOF strategy. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, are applied. Distinct mechano‐bactericidal actions are discussed, including stretching, impaling, and mechanical injury. Abstract Mechano‐bactericidal (MB) surfaces
Zhejian Cao, Santosh Pandit, Francoise M. Amombo Noa, Jian Zhang, Wengeng Gao, Shadi Rahimi, Lars Öhrström, Ivan Mijakovic   +7 more
wiley   +1 more source

Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans. [PDF]

PLoS One
Iwuchukwu NC, Costa ACBPD, Law C, Kim MJ, Mitchell AP, Whiteway M.   +5 more
europepmc   +1 more source

Antimicrobial Activity of Piper betle Ethanolic Leaf Extract on Enterococcus faecalis Biofilm

, 2010
Suparat Khamdang, Jainuch Kanchanapoo, Nipaporn Meungchan, Songpon Sittikanka, Adulsak lhaolaem, Wootthikrai Wilamat, Noppawat Pengkumsri   +6 more
openalex   +1 more source

Multi‐Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend

Advanced Science, EarlyView.
The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He, Jian Xiao, Xiaoqiang Shen, Kankan Zhao, Xiaoyu Lei, Huarui Zhang, Chao Sun, Huijie Lu, Yongqi Shao   +8 more
wiley   +1 more source

Flavonoids interfere with biofilm formation by targeting diguanylate cyclases in multidrug resistant Vibrio cholerae. [PDF]

Sci Rep
Manna T, Dey S, Karmakar M, Jana D, Guchhait KC, Hazra S, Ballav S, Paria S, Zanchi FB, Hossain M, Panda AK, Ghosh C.   +11 more
europepmc   +1 more source