Results 1 to 10 of about 309,362 (294)

Performance of Choline Geranate Deep Eutectic Solvent as Transdermal Permeation Enhancer: An In Vitro Skin Histological Study

Pharmaceutics, 2021
In the present research work, we addressed the changes in skin by which deep eutectic solvents (DES) enhanced transdermal permeation of bioactive compounds and propose a rationale for this mechanism. Several studies showed that these unusual liquids were
Rodrigo Boscariol, Érika A. Caetano, Erica C. Silva, Thais J. Oliveira, Raquel M. Rosa-Castro, Marta M. D. C. Vila, Victor M. Balcão   +6 more
doaj   +1 more source

Translational challenges and opportunities in biofilm science: a BRIEF for the future

npj Biofilms and Microbiomes, 2022
Biofilms are increasingly recognised as a critical global issue in a multitude of industries impacting health, food and water security, marine sector, and industrial processes resulting in estimated economic cost of $5 trillion USD annually.
C. J. Highmore, G. Melaugh, R. J. Morris, J. Parker, S. O. L. Direito, M. Romero, F. Soukarieh, S. N. Robertson, N. C. Bamford   +8 more
doaj   +1 more source

Bicontinuous Cubic Liquid Crystals as Potential Matrices for Non-Invasive Topical Sampling of Low-Molecular-Weight Biomarkers

Pharmaceutics, 2023
Many skin disorders, including cancer, have inflammatory components. The non-invasive detection of related biomarkers could therefore be highly valuable for both diagnosis and follow up on the effect of treatment.
Maxim Morin, Sebastian Björklund, Emelie J. Nilsson, Johan Engblom   +3 more
doaj   +1 more source

Economic significance of biofilms: a multidisciplinary and cross-sectoral challenge

npj Biofilms and Microbiomes, 2022
The increasing awareness of the significance of microbial biofilms across different sectors is continuously revealing new areas of opportunity in the development of innovative technologies in translational research, which can address their detrimental ...
Miguel Cámara, William Green, Cait E. MacPhee, Paulina D. Rakowska, Rasmita Raval, Mark C. Richardson, Joanne Slater-Jefferies, Katerina Steventon, Jeremy S. Webb   +8 more
doaj   +1 more source

Isolation and Molecular Characterization of Two Novel Lytic Bacteriophages for the Biocontrol of Escherichia coli in Uterine Infections: In Vitro and Ex Vivo Preliminary Studies in Veterinary Medicine

Pharmaceutics, 2022
E. coli is one of the etiological agents responsible for pyometra in female dogs, with conventional treatment involving ovariohysterectomy. Here, we report the isolation and full characterization of two novel lytic phages, viz.
Victor M. Balcão, Bianca G. Belline, Erica C. Silva, Pablo F. F. B. Almeida, Denicezar Â. Baldo, Lara R. P. Amorim, José M. Oliveira Júnior, Marta M. D. C. Vila, Fernando S. Del Fiol   +8 more
doaj   +1 more source

Unraveling How Candida albicans Forms Sexual Biofilms. [PDF]

, 2020
Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms.
Hernday, Aaron D, Nobile, Clarissa J, Perry, Austin M   +2 more
core   +1 more source

Bacteriophage-Based Biosensing of Pseudomonas aeruginosa: An Integrated Approach for the Putative Real-Time Detection of Multi-Drug-Resistant Strains

Biosensors, 2021
During the last decennium, it has become widely accepted that ubiquitous bacterial viruses, or bacteriophages, exert enormous influences on our planet’s biosphere, killing between 4–50% of the daily produced bacteria and constituting the largest genetic ...
Liliam K. Harada, Waldemar Bonventi Júnior, Erica C. Silva, Thais J. Oliveira, Fernanda C. Moreli, José M. Oliveira Júnior, Matthieu Tubino, Marta M. D. C. Vila, Victor M. Balcão   +8 more
doaj   +1 more source

Transdermal Permeation Assays of Curcumin Aided by CAGE-IL: In Vivo Control of Psoriasis

Pharmaceutics, 2022
Psoriasis is a clinically heterogeneous skin disease with an important genetic component, whose pathophysiology is not yet fully understood and for which there is still no cure.
Rodrigo Boscariol, Érika A. Caetano, Denise Grotto, Raquel M. Rosa-Castro, José M. Oliveira Junior, Marta M. D. C. Vila, Victor M. Balcão   +6 more
doaj   +1 more source

Capsular Polysaccharide Cross-Regulation Modulates Bacteroides thetaiotaomicron Biofilm Formation

mBio, 2020
Bacteroides thetaiotaomicron is one of the most abundant gut symbiont species, whose contribution to host health through its ability to degrade dietary polysaccharides and mature the immune system is under intense scrutiny.
Nathalie Béchon, Jovana Mihajlovic, Sol Vendrell-Fernández, Florian Chain, Philippe Langella, Christophe Beloin, Jean-Marc Ghigo   +6 more
doaj   +1 more source

ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa

npj Biofilms and Microbiomes, 2022
Pseudomonas aeruginosa uses multiple protein regulators that work in tandem to control the production of a wide range of virulence factors and facilitate rapid adaptation to diverse environmental conditions. In this opportunistic pathogen, ToxR was known
Jean-Frédéric Dubern, Manuel Romero, Anne Mai-Prochnow, Marco Messina, Eleftheria Trampari, Hardeep Naghra-van Gijzel, Kok-Gan Chan, Alessandro M. Carabelli, Nicolas Barraud, James Lazenby, Ye Chen, Shaun Robertson, Jacob G. Malone, Paul Williams, Stephan Heeb, Miguel Cámara   +15 more
doaj   +1 more source