Results 41 to 50 of about 6,165 (159)

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Recursos de bioinformática aplicados às ciências ômicas como genômica, transcriptômica, proteômica, interatômica e metabolômica

Bioscience Journal, 2010
As ciências ômicas tratam da análise global dos sistemas biológicos, integrando diferentes áreas do conhecimento, como a bioquímica, genética, fisiologia e computação, com o objetivo de isolar e caracterizar genes, proteínas e metabólitos, assim como ...
Foued Salmen Espindola, Luciana Karen Calábria, Alexandre Azenha Alves de Rezende, Boscolli Barbosa Pereira, Flávia Assumpção Santana, Isabel Marques Rodrigues Amaral, Janaina Lobato, Juliana Luzia França, Justino Luiz Mario, Leonardo Bruno Figueiredo, Luana Pereira dos Santos, Neire Moura de Gouveia, Rafael Nascimento, Renata Roland Teixeira, Taís Alves dos Reis, Thaise Gonçalves de Araújo   +15 more
doaj  

Gender Medicine in Computed Tomography Radiomics Analysis to Predict Disease Progression in Liver Respectable Colorectal Cancer Patients

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Gender medicine is an evolving discipline that examines how diseases manifest and progress differently in men and women. Tailoring medical therapies and diagnostic approaches can enhance patient outcomes. While radiomics is emerging as a promising tool in personalized medicine, few studies evaluate its role in gender medicine within
Annarita Fanizzi, Arianna Campione, Samantha Bove, Oronzo Brunetti, Deniz Can Guven, Angelo Cirillo, Andrea Lupo, Chiara Macrì, Leonardo Ricchitelli, Alessandro Rizzo, Elsa Vitale, Maria Colomba Comes, Raffaella Massafra   +12 more
wiley   +1 more source

Aplicaciones de la bioinformática en la medicina: el genoma humano. ¿Cómo podemos ver tanto detalle?

Acta Biológica Colombiana, 2016
La bioinformática es un campo novedoso que soporta parte de la investigación biológica dirigida a la identificación de variantes génicas que pueden ser descubiertas desde los estudios de genomas completos.
Clara Isabel Bermudez-Santana
doaj   +1 more source

Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise Bioinformática

Arquivos Brasileiros de Cardiologia
Figura Central : Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise ...
Cheng-Mei Wang, Gang Luo, Ping Liu, Wei Ren, Sijin Yang   +4 more
semanticscholar   +1 more source

South‐to‐Southeast Expansion of HIV‐1 Subtype C in Brazil

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT HIV‐1 group M subtype C (HIV‐1C) is the predominant genetic variant in southern Brazil but has been sparsely detected in other regions of the country. Our study aimed to identify HIV‐1C transmission links across Brazil using phylogenetic reconstruction and to infer trends in geographical patterns and dissemination beyond the southern region ...
Daniel Polita, Laise de Moraes, Marta Giovanetti, Filipe Ferreira de Almeida Rego, Gabriel Carvalho, Luciane Amorim Santos, Ricardo Khouri, Dennis Maletich Junqueira   +7 more
wiley   +1 more source

Identificación de inhibidores de PI3Kα mediante diseño de farmacóforos y reposicionamiento farmacológico†

Horizonte Médico
Objetivo: PI3K es una de las proteínas más comunes que sufren mutaciones en el cáncer, ello genera que se altere su función en la regulación del metabolismo, la inmunidad, entre otros.
Paolo Wong Chero, Daniel Ramirez Lupuche, Richard Zapata Dongo, Stefany Infante Varillas, Juan Enrique Faya Castillo   +4 more
doaj   +1 more source

Impacto del desarrollo de la bioinformática en Cuba

Revista Cubana de Medicina Militar, 2023
La bioinformática es la aplicación de las ciencias informáticas para resolver problemas biológicos. En esta disciplina los recursos computacionales y humanos asisten al análisis de cantidades enormes de datos biológicos, para extraer de ellos información
Lisvan Guevara Trujillo, Barbaro Nicolas Socarras Hernandez   +1 more
doaj  

Identificação de Potenciais Biomarcadores Cruciais em IAMCSST por Meio de Análise Bioinformática Integrada

Arquivos Brasileiros de Cardiologia
Resumo Fundamento O infarto do miocárdio com elevação do segmento ST (IAMCSST) é uma das principais causas de doenças cardiovasculares fatais, que têm sido a principal causa de mortalidade em todo o mundo.
Lizhi Zhao, YinLi Liang, Ting Yin, Hui-Ling Liao, Bo Liang   +4 more
semanticscholar   +1 more source

First Assembly of a Draft Genome of the Critically Endangered Northern Muriqui (Brachyteles hypoxanthus, Primates, Atelidae) Including Non‐Invasive Genotyping Strategies for the Species

Ecology and Evolution, Volume 15, Issue 8, August 2025.
First draft genome assembly of the critically endangered primate northern muriqui (Brachyteles hypoxanthus) and complete mitochondrial genome assembly. Set of microsatellite markers developed for the species for genotyping‐by‐sequencing using high‐throughput sequencing technology and aiming to amplify non‐invasive sampling for population genetics ...
Amanda Alves de Melo‐Ximenes, Romina Batista, Leonardo Carlos Jeronimo Corvalán, Tomas Marques‐Bonet, Lukas Kuderna, Kyle Farh, Jeffrey Rogers, Mariane da Cruz Kaizer, Jean Philippe Boubli, Fabiano Rodrigues de Melo, Rhewter Nunes, Mariana Pires de Campos Telles   +11 more
wiley   +1 more source