Results 61 to 70 of about 257,337 (308)

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

mAbs, 2020
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavorable
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick   +8 more
doaj   +1 more source

Innovative Hybrid-Alignment Annotation Method for Bioinformatics Identification and Functional Verification of a Novel Nitric Oxide Synthase in Trichomonas vaginalis

Biology, 2022
Both the annotation and identification of genes in pathogenic parasites are still challenging. Although, as a survival factor, nitric oxide (NO) has been proven to be synthesized in Trichomonas vaginalis (TV), nitric oxide synthase (NOS) has not yet been
Hung-Che Lin, Hao-Ai Shui, Kuo-Yang Huang, Wei-Zhi Lin, Hsin-Yi Chang, Hwei-Jen Lee, Ying-Chih Lin, Yuahn-Sieh Huang, Guan-Ru Chen, Ya-Ting Yang, Hsiu-Lin Liu, Yi-Syuan Wu, Chia-Shiang Cheng, Ching-Lung Ko, Yu-Tien Chang, Jih-Chin Lee, Chen-Shien Lin, Chih-Hung Wang, Chi-Ming Chu   +18 more
doaj   +1 more source

The Roots of Bioinformatics

PLoS Computational Biology, 2010
Every new scientific discipline or methodology reaches a point in its maturation where it is fruitful for it to turn its gaze inward, as well as backward. Such introspection helps to clarify the essential structure of a field of study, facilitating communication, pedagogy, standardization, and the like, while retrospection aids this process by ...
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Left ventricular assist device bioinformatics identify possible hubgenes and regulatory networks involved in the myocardium of patients with left ventricular assist device

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThe aim of this study was to clarify the changes of myocardial gene expression profile after left ventricular assist device (LVAD) implantation and the related molecular biological significance.MethodsA thorough bioinformatic analysis to ...
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang, Lei Huang, Lei Huang, Lei Huang   +7 more
doaj   +1 more source

Bioinformatic Pipeline for designing conditional guide RNAs

, 2023
Supplemental files for graduate thesis containing genbank files of plasmid constructs used and bioinformatic tools used for design of conditional guide ...
Chen, Zhewei
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Introduction to Bioinformatics

, 2019
How the scientific community looks at molecular biology today is very different from that 50 years ago. During this time technological developments have led to many significant findings that have shook one of the most important foundations of molecular biology: the central dogma.
AYYILDIZ, DILARA, Piazza S.
openaire   +3 more sources

Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification

Frontiers in Endocrinology
BackgroundLipodystrophy is a rare disease that is poorly diagnosed due to its low prevalence and frequent phenotypic heterogeneity. The main therapeutic measures for patients with clinical lipodystrophy are aimed at improving general metabolic ...
Zhiwen Cao, Zhiwen Cao, Yuxiao Zhao, Yuxiao Zhao, Ruixin Liu, Ruixin Liu, Xialin Yan, Jiqiu Wang, Jiqiu Wang, Na Chen   +9 more
doaj   +1 more source

Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level

International Journal of General Medicine, 2021
Xinyang Wang,1,* Dandan Xue,1,* Xiaoxia Zhu,2,* Rui Geng,3 Xin Bao,2 Xiang Chen,2 Tiansong Xia1,4 1Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department ...
Wang X, Xue D, Zhu X, Geng R, Bao X, Chen X, Xia T   +6 more
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