Results 171 to 180 of about 257,337 (308)

The growth of bioinformatics [PDF]

Briefings in Bioinformatics, 2006
openaire   +2 more sources

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Rapid identification of microbial pathogens and antimicrobial resistance from bloodstream infections using long-read sequencing. [PDF]

Microb Genom
Lerminiaux N, Fakharuddin K, Adam HJ, Bharat A, Golding GR, Martin I, Mulvey M, Mataseje LF.   +7 more
europepmc   +1 more source

Bioinformatic analysis of metabarcoding data using DADA2 - Theoretical part

The presentation, delivered during the BIOLAWEB Virtual Training in May-June 2024, provides a comprehensive theoretical foundation for understanding bioinformatic workflows in DNA metabarcoding.BIOLAWEB Virtual training - Bioinformatic (May-June ...
Lemonnier, Clarisse
core  

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Editorial: AI and Multi-Omics for Rare Diseases: Challenges, Advances and Perspectives

Frontiers in Molecular Biosciences, 2021
Silvia Bottini, Frank Emmert-Streib, Leonardo Franco   +2 more
doaj   +1 more source

Bioinformatic Resistome Profiling of Metal Tolerance Mechanisms in Endodontic Infections: Implications for Antimicrobial Nanoparticle-Based Biomaterials. [PDF]

J Funct Biomater
Luna-Lara CA, Luna-Dominguez CR, Oliver-Parra R, Criollo-Barrios OV, Vaca-Jasso MLD, Salas-Orozco MF.   +5 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Microbial cell-free DNA for rapid pathogen identification in clinical diagnostics: a proof of concept study. [PDF]

Genome Med
Banz M, Hagel S, Freiburger S, Huhn F, Krause M, Glöckner S, Löffler B, Nurjadi D, Muthukumarasamy U, Jundzill M, Kaasch AJ, Pletz MW, Brandt C.   +12 more
europepmc   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source