Results 191 to 200 of about 280,000 (306)

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Rapid and consistent genetic clustering of environmental Legionella pneumophila isolates using accessible single-step WGS analysis tools. [PDF]

PLoS One
Schmidt H, Bikár SE, Lieb B, Lotz D, Brand T, Brandstetter M, Hankeln T, Michel A, Plachter B, Kohnen W.   +9 more
europepmc   +1 more source

An Efficient Biological Codon Recognition Reservoir Computing System Based on Low‐Energy Epitaxial Hf0.52Zr0.48O2 Ferroelectric Memristors

Advanced Science, EarlyView.
This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu, Jikang Xu, Yongqing Jia, Wenxuan Wang, Weifeng Zhang, Biao Yang, Xiaobing Yan   +6 more
wiley   +1 more source

Comparison of library preparation protocols and bioinformatic pipelines in high-throughput 16S rRNA gene sequencing. [PDF]

BMC Microbiol
Andersson O, Fagerström A, Dannenberg K, Kekki J, Rode J, Rangel I, Lindqvist CM, Stenmark B.   +7 more
europepmc   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Candidate Stress-Specific microRNA Expression in Pediatric Thrombosis and Healthy Children: A Comparative Analysis of Serum miR-34a-5p in Relation to Stress Levels and Inflammatory Genetic Traits. [PDF]

Genes (Basel)
Gintoni I, Damaskopoulou E, Siouti Z, Baldouni K, Skoufou M, Pachis N, Dettoraki A, Michalopoulou A, Pergantou H, Vlachakis D, Chrousos GP, Yapijakis C.   +11 more
europepmc   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Bioinformatic pipeline to identify candidate mRNA transcripts targeted by the putative Regulated Ire1-Dependent Decay pathway of <i>Dictyostelium discoideum</i> . [PDF]

MicroPubl Biol
Bingham C, Taylor-Cornejo E.
europepmc   +1 more source

Molecular and bioinformatic approaches to dissect the structure and function of antifungal peptides from filamentous fungi

MOLECULAR AND BIOINFORMATIC APPROACHES TO DISSECT THE STRUCTURE AND FUNCTION OF ANTIFUNGAL PEPTIDES FROM FILAMENTOUS FUNGI Molecular and bioinformatic approaches to dissect the structure and function of antifungal peptides from filamentous fungi ...
Cairns, Claudia Anna
core  

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source