Results 161 to 170 of about 213,652 (265)

A conditional multi-signal validation framework for cancer immunotherapy: the adaptive anti-error biological system. [PDF]

Front Immunol
Kalondero EM.
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Erratum: Discovering Novel Biomarkers Associated with the Pathogenesis of Psoriasis: Evidence from Bioinformatic Analysis [Corrigendum]. [PDF]

Int J Gen Med
europepmc   +1 more source

The Necessity of POMC and MC3R Analysis in the First-Level Diagnosis of Monogenic Obesity: The Experience of Two Italian Centers. [PDF]

Genes (Basel)
Miedviedieva K, Regoli T, Marchisotta S, Sessa L, Blasco M, Leanza S, Ciuoli C, Cantore A, Ricci C, Cantara S.   +9 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub-Saharan Africa: A Narrative Review. [PDF]

Health Sci Rep
Ofosu W, Kotey FCN, Odoom A, Ntim OK, Donkor ES.   +4 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Integrated Reanalysis of Global Riverine Fish eDNA Datasets Shows Robustness and Congruence of Biodiversity Conclusions. [PDF]

Mol Ecol
Zhang Y, Zhang H, Akashi H, Albouy CP, Andres KJ, Barquín J, Brantschen J, Connon RE, Craine JM, Gleeson D, Goldenberg-Vilar A, González-Ferreras AM, Hatzenbuhler C, Hupało K, Hyde J, Iwasaki W, Johnson MD, Katz AD, Kuzovlev VV, Larson CE, Lecaudey LA, Leese F, Leray M, Li F, Macher TH, Mauvisseau Q, Morán-Luis M, Nester G, Quintero H, Ravelomanana T, Chacko MR, Saccò M, Sales N, Schenekar T, Schletterer M, Schmidt S, Schulte NO, Schütz R, Sperry JH, Stevens ER, Stinson SA, Weiss S, Xia F, Zhang H, Zhang S, Zhong W, Zong S, Pellissier L, Zhang X, Altermatt F.   +49 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Special Issue "Repetitive DNA". [PDF]

Int J Mol Sci
Šatović-Vukšić E, Garrido-Ramos MA, Plohl M.   +2 more
europepmc   +1 more source