Results 31 to 40 of about 224,047 (264)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis

Frontiers in Endocrinology, 2020
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Epidemiological findings revealed that women with PCOS are prone to develop certain cancer types due ...
Verónica Yumiceba, Andrés López-Cortés, Andrés López-Cortés, Andy Pérez-Villa, Iván Yumiseba, Santiago Guerrero, Jennyfer M. García-Cárdenas, Isaac Armendáriz-Castillo, Patricia Guevara-Ramírez, Paola E. Leone, Ana Karina Zambrano, César Paz-y-Miño   +11 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Immunoinformatics-Based development of a Multi-Epitope vaccine candidate targeting coinfection by Klebsiella pneumoniae and Acinetobacter baumannii

BMC Infectious Diseases
Background The increasing prevalence of multidrug-resistant (MDR) pathogens in clinical settings underscores the urgent need for effective therapeutic strategies. Among these, ESKAPE pathogens such as Acinetobacter baumannii and Klebsiella pneumoniae are
Gul Afshan, Namrah Yaseen, Syed H Ali, Asad U. Khan   +3 more
doaj   +1 more source

Proteomic and metabolomic analyses reveal the novel targets of spermine for alleviating diabetic cardiomyopathy in type II diabetic mice

Frontiers in Cardiovascular Medicine, 2022
Diabetic cardiomyopathy (DCM) is one of the most serious complications of diabetes. Recent cardiology studies suggest that spermine has a cardioprotective effect.
Jian Sun, Jiyu Xu, Yong Liu, Xiaoyi Xu, Shumin Zhang, Yankun Hao, Yitong Lin, Yue Han, Feiya Li, Hui Yuan, Hui Yuan   +10 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility

Biology, Medicine & Natural Product Chemistry, 2020
The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility.
Mohamad Amin, Muhammad Najib Fahmi, Muhammad Andi Ali Ridho, Nurul Fitri, Umie Lestari, Dina Maulina, Ihya Fakhrurizal Amin   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Upregulation of sperm-associated antigen 5 expression in endometrial carcinoma was associated with poor prognosis and immune dysregulation, and promoted cell migration and invasion

Scientific Reports
Sperm-associated antigen 5 (SPAG5) regulates cancer cell invasion and is involved in the progression of many cancers. However, the role of SPAG5 in endometrial carcinoma (EC) is still unknown. The purpose of this study was to explore the role of SPAG5 in
Manru Chen, Dan Wang, Yanyu Xu, Chenggang Yang   +3 more
doaj   +1 more source

Virtual Prediction of The Effect Phenolic And Glucosinolate Compounds In Broccoli (Brassica Oleracea) On Anti-aging As Stimulant Nrf-2

Journal of Experimental Life Science, 2020
Aging is caused by an imbalance between antioxidants and ROS. Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant genes. Under normal conditions, Nrf2 will bind keap1 and cause degradation of Nrf2. Nrf2
Viona Faiqoh Hikmawati, Fajar Mustika Alam, Jihan Shavira Ainnayah, Fatchiyah Fatchiyah   +3 more
doaj   +1 more source