Results 121 to 130 of about 1,477,984 (353)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

InCoB2012 Conference: from biological data to knowledge to technological breakthroughs

BMC Bioinformatics, 2012
Ten years ago when Asia-Pacific Bioinformatics Network held the first International Conference on Bioinformatics (InCoB) in Bangkok its theme was North-South Networking. At that time InCoB aimed to provide biologists and bioinformatics researchers in the
Schönbach Christian, Tongsima Sissades, Chan Jonathan, Brusic Vladimir, Tan Tin, Ranagathan Shoba   +5 more
doaj   +1 more source

Bioinformatics-Aided Venomics

Toxins, 2015
Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well as ...
Quentin Kaas, David J. Craik
doaj   +1 more source

BIOINFORMATICS APPROACH ON ACTION AND MECHANISM OF BROMELAIN IN HEPATOCELLULAR CARCINOMA

, 2021
Sushma S. Murthy, Bala Narsaiah T
openalex   +2 more sources

Identification of hub genes in triple-negative breast cancer by integrated bioinformatics analysis [PDF]

, 2021
Limin Wei, Xinyang Li, Ziming Wang, Yukun Wang, Ge Yao, Jiahao Fan, Xinshuai Wang   +6 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson’s Disease [PDF]

, 2022
Longping Yao, Kai Lin, Zijian Zheng, Sümeyye Koç, Shizhong Zhang, Guohui Lu, Thomas Skutella   +6 more
openalex   +1 more source

Cloud Bioinformatics in a private cloud deployment

, 2013
This chapter describes service portability for a private cloud deployment, including a detailed case study about Cloud Bioinformatics services developed as part of the Cloud Computing Adoption Framework (CCAF).
Chang, Victor
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Computational Overhead Across Prioritizing Bioinformatics Traffic Packet Operations by Differentiated Services Code Point (DSCP)

IEEE Access
The purpose of this research is to examine the results of applying DSCP in order to learn how it affects bioinformatics network efficiency and performance under different types of bioinformatics traffic.
Ala Abdulsalam Alarood
doaj   +1 more source