Results 241 to 250 of about 1,289,019 (331)

Mathematical Bioinformatics [PDF]

, 2015

core  

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

AutoGERN: single-cell RNA-seq gene regulatory network inference via explicit link modeling and adaptive architectures. [PDF]

Bioinformatics
Wang J, Chen Y, Zou Q, Luo X.
europepmc   +1 more source

Using Bioinformatics and Machine Learning Techniques to Identify Potential Genes that may be Associated with Lung Cancer and Facilitate the Screening of Such Genes

Zeynep Küçükakçalı, İpek Balıkçı Çiçek   +1 more
openalex   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Statement of Retraction: MicroRNA-592 serves as a novel tumor suppressor in Uveal melanoma: bioinformatics analysis and in vitro cell function verification. [PDF]

Bioengineered
europepmc   +1 more source

Managing workflow executions with WESkit. [PDF]

Bioinformatics
Schneider-Lunitz V, Kensche PR, Kraatz L, Strubel P, Borufka S, Parala G, Kanitz A, Eils R, Buchhalter I, Twardziok SO.   +9 more
europepmc   +1 more source

Bioinformatics Project "Integrative Sequence, Structural and Docking Analysis of Class-A β- Lactamase (TEM-1, PDB: 1BTL) to Investigate Antibiotic Resistance Mechanisms"

Name -Deepak Kumar, Deepak Kumar Malav
openalex   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Community-led standards for global wastewater-based infectious disease surveillance. [PDF]

PLOS Glob Public Health
Smith EA, Ahmadi Jeshvaghane M, Pilz DA, Shitindo M, Costa da Silva J, Gable L, Brown K, Calvert-Joshua T, Diedericks F, Ünal G, Paull JS, Shukla NB, Muhammad Z, Amofa JO, Liu EJ, Griffiths EJ, Landgraff C, Guerfali FZ, Tiffin N, Levy JI, Public Health Alliance for Genomic Epidemiology (PHA4GE) Wastewater Surveillance Working Group.   +20 more
europepmc   +1 more source