Results 271 to 280 of about 1,289,019 (331)

iModMix: integrative module analysis for multi-omics data. [PDF]

Bioinformatics
Narváez-Bandera I, Lui A, Mekonnen YA, Rubio V, Takyi A, Sulman N, Wilson C, Ackerman HD, Ospina OE, Gonzalez-Calderon G, Flores ER, Li Q, Chen A, Fridley BL, Stewart PA.   +14 more
europepmc   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Sparse dimensionality reduction for analyzing single-cell-resolved interactions. [PDF]

Bioinform Adv
Brunn N, Hackenberg M, Fullio CL, Vogel T, Binder H.   +4 more
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Machine learning improves SNP microarray performance in challenged samples. [PDF]

Bioinform Adv
Chiao A, Crysup B, King JL, Coble MD, Woerner AE.   +4 more
europepmc   +1 more source

153eP The oncogenic role of SNORD17 in skin cutaneous melanoma: A comprehensive bioinformatics analysis

C. Aydin Acar, Gökhan Görgişen
openalex   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

DrugBLIP: exploring the protein-molecule interaction mechanisms with a multi-task learning graph transformer. [PDF]

Bioinformatics
Wang R, Gao X, Zhao P.
europepmc   +1 more source

Adaptive Evolution-Inspired Algorithm for Intrusion Detection in Bioinformatics Systems. [PDF]

Evol Bioinform Online
Alam M, Samal CK, Ali A, Alourani A.
europepmc   +1 more source