Results 291 to 300 of about 1,477,984 (353)

Harnessing Genomic and Bioinformatics for Surveillance of Pathogens in Africa: A Scoping Review of Existing Training and Gaps in Training

Kingpriest P, Bok J, Lompo P, Ngelesi E, Mwaka J, Ndure SL, Moremi N, Baraka V, Bossche TVD, Bombaywala S, Mesuere B, Martens L, Lang T.   +12 more
europepmc   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Molecular-level protein semantic learning via structure-aware coarse-grained language modeling. [PDF]

Bioinformatics
Zhang J, Weng X, Zhu T, Liu Y, Zhu Z.
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration. [PDF]

Brief Bioinform
Khan AM, Goto S, Nakai K, Wong L, Kovats DE, Saito Y, Ikematsu S, Yamanishi Y, Wahid NSC, Singh H, Eranti P, Chen YP, Kim TM, Ho SY, Mar JC, Iwasaki W, Valadi J, Suravajhala P, Schönbach C, Tan TW, Ranganathan S, Aoki-Kinoshita KF.   +21 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud. [PDF]

PLoS Comput Biol
Bradford J, Joy D, Winsen M, Meurant N, Wilkins M, Wilson LOW, Bauer DC, Perrin D.   +7 more
europepmc   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Bioinformatics analysis and preliminary functional study of proteins associated with arsenic metabolism and resistance

, 2007
Shiyang Wu
openalex   +1 more source

RCSB Protein Data Bank: Delivering integrative structures alongside experimental structures and computed structure models. [PDF]

Nucleic Acids Res
Vallat B, Rose Y, Piehl DW, Duarte JM, Bittrich S, Bi C, Segura J, Zalevsky A, Sekharan MR, Webb BM, Bhikadiya C, Voigt M, Henry J, Chao H, Pingale A, Raymond D, Sagendorf J, Peisach E, Feng Z, Guranovic V, Smith J, Rose AS, Young JY, Berman HM, Sali A, Burley SK.   +25 more
europepmc   +1 more source