Results 11 to 20 of about 176,199 (305)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

Biologia molecular dos meningiomas

open access: yesJBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA, 2018
Meningiomas são tumores benignos que, algumas vezes, podem comportar-se de modo agressivo e/ou recorrente. Até o momento não há marcadores clínicos ou laboratoriais fidedignos que possam predizer como esta neoplasia evoluirá. Dessa forma, faz-se necessário o desenvolvimento de uma alternativa efetiva de tratamento quando não for possível a ressecção ...
Pedro Augustto de Santana Júnior   +2 more
openaire   +2 more sources

Lipid dynamics at dendritic spines

open access: yesFrontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
Carlos Gerardo Dotti   +2 more
doaj   +1 more source

Ser or Leu: Structural Snapshots of Mistranslation in Candida albicans

open access: yesFrontiers in Molecular Biosciences, 2014
Candida albicans is a polymorphic opportunistic fungal pathogen normally residing as commensal on mucosal surfaces, skin and gastrointestinal and genitourinary tracts. However, in immunocompromised patients C.
Zsuzsa eSarkany   +3 more
doaj   +1 more source

Trinucleotide Repeats: A structural perspective

open access: yesFrontiers in Neurology, 2013
Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function ...
Bruno eAlmeida   +3 more
doaj   +1 more source

Resveratrol Administration Increases Transthyretin Protein Levels, Ameliorating AD Features: The Importance of Transthyretin Tetrameric Stability

open access: yesMolecular Medicine, 2016
Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR).
Luís Miguel Santos   +5 more
doaj   +1 more source

Functional Insights From KpfR, a New Transcriptional Regulator of Fimbrial Expression That Is Crucial for Klebsiella pneumoniae Pathogenicity

open access: yesFrontiers in Microbiology, 2021
Although originally known as an opportunistic pathogen, Klebsiella pneumoniae has been considered a worldwide health threat nowadays due to the emergence of hypervirulent and antibiotic-resistant strains capable of causing severe infections not only on ...
Ana Érika Inácio Gomes   +6 more
doaj   +1 more source

La Biologia molecular vista per un físic [PDF]

open access: yesRevista de física, 1994
Puigdomènech i Rosell, Pere
core   +2 more sources

How Listeria monocytogenes organizes its surface for virulence

open access: yesFrontiers in Cellular and Infection Microbiology, 2014
Listeria monocytogenes is a Gram-positive pathogen responsible for the manifestation of human listeriosis, an opportunistic foodborne disease with an associated high mortality rate.
Filipe eCarvalho   +2 more
doaj   +1 more source

Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease [PDF]

open access: yes, 2013
Cystic ovarian disease (COD) is one of the main factors responsible for reproductive disorders in cattle. Although the pathogenesis and mechanism of cyst formation are not fully understood, it has been proposed that the IGF system could play an essential
Barbeito, Claudio Gustavo   +6 more
core   +3 more sources

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