Results 21 to 30 of about 55,587 (249)

Grupo de interesse em Biologia Molecular

, 2022
A biologia molecular é uma área da biologia que se centra na utilização de técnicas baseadas no estudo de DNA, RNA e proteínas. Esta é, também, uma área transversal a virtualmente todas as áreas de investigação científica na atualidade. O recentemente formado Grupo de Interesse em Biologia Molecular (GIBioM) da FMV da Universidade Lusófona tem por ...
Ropio, Joana, Valença, Andreia, Belas, Adriana, Amaral, Ana, Pires, Ana Elisabete, Marques, Cátia, Batista, Mariana, Serafim, Michelle Karen Brasil, Van Harten, Sofia, Alves, Maria Margarida Ferreira   +9 more
openaire   +2 more sources

Centrosome polarization in T cells: a task for formins

Frontiers in Immunology, 2013
T-cell antigen receptor (TCR) engagement triggers the rapid reorientation of the centrosome, which is associated with the secretory machinery, towards the immunological synapse (IS) for polarized protein trafficking.
Laura eAndrés-Delgado, Olga Maria Antón, Miguel Angel Alonso   +2 more
doaj   +1 more source

How Listeria monocytogenes organizes its surface for virulence

Frontiers in Cellular and Infection Microbiology, 2014
Listeria monocytogenes is a Gram-positive pathogen responsible for the manifestation of human listeriosis, an opportunistic foodborne disease with an associated high mortality rate.
Filipe eCarvalho, Sandra eSousa, Didier eCabanes   +2 more
doaj   +1 more source

Metabolic Adaptation of Paracoccidioides brasiliensis in Response to in vitro Copper Deprivation

Frontiers in Microbiology, 2020
Copper is an essential micronutrient for the performance of important biochemical processes such as respiration detoxification, and uptake of metals like iron.
Guilherme Petito, Guilherme Petito, Juliana Santana de Curcio, Maristela Pereira, Alexandre Melo Bailão, Juliano Domiraci Paccez, Gabriel Brum Tristão, Camila Oliveira Barbosa de Morais, Marcelo Valle de Souza, Agenor de Castro Moreira Santos, Wagner Fontes, Carlos André Ornelas Ricart, Célia Maria de Almeida Soares   +12 more
doaj   +1 more source

Microbiological indicators of recovery soil quality in a agroforestry system

Acta Brasiliensis, 2018
The verification of soil quality is an important tool to monitor its degradation, and to plan the implementation of sustainable management practices. The objective of this study was to evaluate soil quality in three agroforestry systems located in the ...
Paulo Agenor Alves Bueno, Dr, Vitória Maria Teodoro de Oliveira, Srta, Bruna Lopes Gualdi, Srta, Pedro Henrique Nascimento Silveira, Sr, Rafael Gon Pereira, Sr, Caio Evandro Santos de Freitas, Sr, Raquel de Oliveira Bueno, Dra, Elizabete Satsuki Sekine, Dra, Kaiser Dias Schwarcz, Dr   +8 more
doaj   +1 more source

A revolução verde e a biologia molecular

Revista de Ciências Agrárias, 2009
No virar deste século foram identificados os genes responsáveis pela redução da estatura das variedades de trigo e de arroz que possibilitaram a chamada Revolução Verde dos anos sessenta. Mais recentemente, foi demonstrado que esta alteração da arquitectura das plantas resulta da ausência da acção das giberelinas, as hormonas responsáveis pelo ...
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

BMC Biotechnology, 2019
Background Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects.
Maria José Chiabai, Juliana Franco Almeida, Mariana Gabriela Dantas de Azevedo, Suelen Soares Fernandes, Vanessa Bastos Pereira, Raffael Júnio Araújo de Castro, Márcio Sousa Jerônimo, Isabel Garcia Sousa, Leonora Maciel de Souza Vianna, Anderson Miyoshi, Anamelia Lorenzetti Bocca, Andrea Queiroz Maranhão, Marcelo Macedo Brigido   +12 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source