Results 11 to 20 of about 176,610 (307)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Lipid dynamics at dendritic spines

Frontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
Carlos Gerardo Dotti, Jose Antonio Esteban, Maria Dolores eLedesma   +2 more
doaj   +1 more source

Ser or Leu: Structural Snapshots of Mistranslation in Candida albicans

Frontiers in Molecular Biosciences, 2014
Candida albicans is a polymorphic opportunistic fungal pathogen normally residing as commensal on mucosal surfaces, skin and gastrointestinal and genitourinary tracts. However, in immunocompromised patients C.
Zsuzsa eSarkany, Alexandra eSilva, Pedro José Barbosa Pereira, Sandra eMacedo-Ribeiro   +3 more
doaj   +1 more source

The ubiK protein is an accessory factor necessary for bacterial Ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ [PDF]

, 2017
Ubiquinone (UQ), also referred to as coenzyme Q, is a widespread lipophilic molecule in both prokaryotes and eukaryotes in which it primarily acts as an electron carrier.
Aussel, Laurent, Barras, Frédéric, Casadesús Pursals, Josep, Chehade, Mahmoud Hajj, Faivre, Bruno, Fyfe, Cameron David, Hernández Piñero, Sara Belén, Loiseau, Laurent   +7 more
core   +1 more source

Trinucleotide Repeats: A structural perspective

Frontiers in Neurology, 2013
Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function ...
Bruno eAlmeida, Sara eFernandes, Isabel A. Abreu, Sandra eMacedo-Ribeiro   +3 more
doaj   +1 more source

Functional Insights From KpfR, a New Transcriptional Regulator of Fimbrial Expression That Is Crucial for Klebsiella pneumoniae Pathogenicity

Frontiers in Microbiology, 2021
Although originally known as an opportunistic pathogen, Klebsiella pneumoniae has been considered a worldwide health threat nowadays due to the emergence of hypervirulent and antibiotic-resistant strains capable of causing severe infections not only on ...
Ana Érika Inácio Gomes, Thaisy Pacheco, Cristiane da Silva dos Santos, José Aires Pereira, Marcelo Lima Ribeiro, Michelle Darrieux, Lúcio Fábio Caldas Ferraz   +6 more
doaj   +1 more source

High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in bolivian children living in an endemic area [PDF]

, 1994
Submitted by sandra infurna (sinfurna@uol.com.br) on 2016-06-29T15:31:55Z No. of bitstreams: 1 carlos20_morel_etal_IOC_1994.pdf: 578671 bytes, checksum: 49c1bfe1a3334487aede673ca532654a (MD5)Approved for entry into archive by sandra infurna (sinfurna ...
Bosseno, Marie-France, Brenière, Simone Frédérique, Britto, C., Cardoso, M.A., Morel, C.M., Wincker, P., Yaksic, N.   +6 more
core   +1 more source

Resveratrol Administration Increases Transthyretin Protein Levels, Ameliorating AD Features: The Importance of Transthyretin Tetrameric Stability

Molecular Medicine, 2016
Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR).
Luís Miguel Santos, Daniela Rodrigues, Mobina Alemi, Sara Costa Silva, Carlos Alexandre Ribeiro, Isabel Cardoso   +5 more
doaj   +1 more source

In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection [PDF]

, 2011
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas.
Bernardo AS Pereira, Franklin S Silva, Karina M Rebello, Marcel Marín-Villa, Yara M Traub-Cseko, Thereza CB Andrade, Álvaro L Bertho, Ernesto R Caffarena, Carlos R Alves   +8 more
core   +2 more sources

Sceloporus megalepidurus [PDF]

, 2006
Number of Pages: 5Integrative BiologyGeological ...
Chiszar, David, Liner, Ernest A., Mendoza-Quijano, Fernando, Perez-Higareda, Gonzalo, Smith, Hobart M.   +4 more
core   +1 more source