Results 1 to 10 of about 244,108 (120)

Prospects for plasma protein products in China

Zhongguo shuxue zazhi, 2022
Plasma protein products, essential drugs for various clinical diseases, are therapeutic biological products extracted from healthy human plasma. The research and development of new plasma protein products, led by United States and European, has been ...
Changyong JIAN, Fangyu DONG, Chen CHEN, An ZHOU, Jiuyue ZHOU, Xue DONG, Cuiping ZHANG, Dianwei SONG, Bo ZHOU, Shan MA   +9 more
doaj   +1 more source

Method for the detection of human immunoglobulin Fc function based on surface plasmon resonance: preliminary establishment and validation

Zhongguo shuxue zazhi, 2022
Objective To establish a method for detecting human immunoglobulin Fc function based on surface plasmon resonance technology. Methods Based on the characteristic that FcγRI can be binded to the Fc segment of IgG, the affinity constant of the sample was ...
Fangyu DONG, Jiuyue ZHOU, Chen CHEN, An ZHOU, Dianwei SONG, Jianfeng GAO, Xi CHEN, Xiao LI, Jiawei WU, Jiacheng DU, Bo ZHOU, Changyong JIAN   +11 more
doaj   +1 more source

VERITAS: Harnessing the power of nomenclature in biologic discovery

mAbs, 2023
We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision.
Riti Biswas, Ed Belouski, Kevin Graham, Michelle Hortter, Marissa Mock, Christine E. Tinberg, Alan J. Russell   +6 more
doaj   +1 more source

Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

Journal of Nutrition and Metabolism, 2023
Background. Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more ...
Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee   +4 more
doaj   +1 more source

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

mAbs, 2023
Biologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient administration to
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano   +46 more
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Possible potential of Astrodaucus genus in development of anticancer drugs [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Many pharmaceutical factories have dramatically improved the quality of herbal remedies in cancer treatment. The results of somestudies have shown anticancer effect of Astrodaucus genus.
Narges Ghorbani Hesari, Zahra Tofighi, Seyedeh Fatemeh Shirmardi, Seyed Mostafa Hashemi, Abbas Hadjiakhoondi, Saied Goodarzi   +5 more
doaj   +1 more source

Spatial Downscaling of GPM Satellite Precipitation Data Using Extreme Random Trees

Atmosphere, 2023
Obtaining precise and detailed precipitation data is crucial for analyzing watershed hydrology, ensuring sustainable water resource management, and monitoring events such as floods and droughts.
Shaonan Zhu, Xiangyuan Wang, Donglai Jiao, Yiding Zhang, Jiaxin Liu   +4 more
doaj   +1 more source

First record of troglobitic Bothriuridae (Scorpiones) in Australia from the Pilbara [PDF]

Subterranean Biology
We report the first troglobitic members of the scorpion family Bothriuridae from Australia, discovered in the Pilbara region of Western Australia, and provide a brief review of Australian troglofaunal scorpions.
Michael Curran, Syngeon Rodman, Joel Huey, Stephanie Floeckner, Nihara Gunawardene, Morgan Lythe, Dean Main   +6 more
doaj   +3 more sources

Effect of BIO-PLY^TM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages

Viruses, 2022
Porcine Reproductive and Respiratory Syndrome (PRRS) is the one of the most devastating diseases impacting the swine industry worldwide. Control and prevention methods rely on biosafety measures and vaccination.
Alba Frias-De-Diego, Jessica M. Gilbertie, Frank Scholle, Sarah Dejarnette, Elisa Crisci   +4 more
doaj   +1 more source

Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in Odaph C41*/C41* mice

Scientific Reports, 2021
Mutations of Odontogenesis-Associated Phosphoprotein (ODAPH, OMIM *614829) cause autosomal recessive amelogenesis imperfecta, however, the function of ODAPH during amelogenesis is unknown.
Tian Liang, Yuanyuan Hu, Kazuhiko Kawasaki, Hong Zhang, Chuhua Zhang, Thomas L. Saunders, James P. Simmer, Jan C.-C. Hu   +7 more
doaj   +1 more source