Results 21 to 30 of about 310,970 (312)

Atropine Differentially Modulates ECM Production by Ocular Fibroblasts, and Its Ocular Surface Toxicity Is Blunted by Colostrum

open access: yesBiomedicines, 2020
Background: The etiology and the mechanism behind atropine treatment of progressive myopia are still poorly understood. Our study addressed the role of scleral and choroidal fibroblasts in myopia development and atropine function.
Martina Cristaldi   +6 more
doaj   +1 more source

Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons

open access: yesScientific Reports, 2020
During development of the peripheral taste system, oral sensory neurons of the geniculate ganglion project via the chorda tympani nerve to innervate taste buds in fungiform papillae. Germline deletion of the p75 neurotrophin receptor causes dramatic axon
Tao Tang   +5 more
doaj   +1 more source

T-Cell Dependent Immunogenicity of Protein Therapeutics Pre-clinical Assessment and Mitigation–Updated Consensus and Review 2020

open access: yesFrontiers in Immunology, 2020
Immune responses to protein and peptide drugs can alter or reduce their efficacy and may be associated with adverse effects. While anti-drug antibodies (ADA) are a standard clinical measure of protein therapeutic immunogenicity, T cell epitopes in the ...
Vibha Jawa   +7 more
doaj   +1 more source

Advances in Stem Cell Therapies for Rotator Cuff Injuries

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains ...
Hao-Nan Wang   +4 more
doaj   +1 more source

The Effect of Biologics in the Treatment of Multisystem Inflammatory Syndrome in Children (Mis-C): A Single-Center Propensity-Score-Matched Study

open access: yesChildren, 2023
Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as a complication of SARS-CoV-2 infection in children.
Ozge Basaran   +13 more
doaj   +1 more source

A potential new biological marker of the biological age [PDF]

open access: yesFrontiers in Genetics, 2013
For many years, data have been accumulated which point to a significant similarity between the nature of the brain damage in the aging process (in the case of dementia or even in outwardly healthy elderly people) and the brain damage caused by prion diseases of humans and animals (Sobel, 1970; Fraser and McBride, 1985; Masters et al., 1985; Gajdusek ...
Zuev, Victor A.   +2 more
openaire   +3 more sources

Acceptance and use of corporal punishment among parents of biologic and non-biologic children. [PDF]

open access: yes, 2006
Objective: Differences between biologic and non-biologic parents' acceptance and use of ordinary corporal punishment and use of explaining/reasoning as a disciplinary tool are examined from a sociobiological theoretical perspective.
Hall, Ellie Tiedeman
core   +1 more source

Biologic Disease-Modifying Antirheumatic Drugs for Preventing Radiographic Progression in Psoriatic Arthritis: A Systematic Review and Network Meta-Analysis

open access: yesPharmaceutics, 2022
The prevention of joint deformity is among the most important treatment goals of psoriatic arthritis. Some biologics disease-modifying antirheumatic drugs (bDMARDs) have been demonstrated to be effective for both the skin and joints, as well as for ...
Szu-Hsuan Wang   +4 more
doaj   +1 more source

Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation

open access: yesHealth Technology Assessment, 2021
Background: Rheumatoid arthritis is a chronic autoimmune disease that primarily causes inflammation, pain and stiffness in the joints. People with severe disease may be treated with biological disease-modifying anti-rheumatic drugs, including tumour ...
Irina A Tikhonova   +11 more
doaj   +1 more source

SARS-CoV-2 infection and COVID19 vaccination across eight immune-mediated inflammatory disorders: A prospective, real-life Belgian cohort study – the BELCOMID study

open access: yesFrontiers in Immunology, 2023
BackgroundThe risks and impact of COVID19 disease and vaccination in patients with Immune Mediated Inflammatory Diseases (IMID) remain incompletely understood.
Jeroen Geldof   +19 more
doaj   +1 more source

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