Results 171 to 180 of about 8,290,554 (306)

The Utilization of the Completeness of Surgery Index in Revision Endoscopic Sinus Surgery Patients on Biologic Therapy for CRSwNP. [PDF]

Int Forum Allergy Rhinol
Thapar I, Mitchell MB, Patel SD, Talati V, Douglas JE, Kohanski MA, Holbrook EH, Gray ST, Bleier BS, Adappa ND, Palmer JN, Workman AD.   +11 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Clinical Characteristics and Predictors of Primary Non-Response to Biologic Therapy in Rheumatoid Arthritis and Axial Spondyloarthritis. [PDF]

Mediterr J Rheumatol
Beke KS, Kaplan H, Cengiz G, Cüce İ, Kara H, Mustafa Ç, Kırnap M.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Scaling the RNA Summit: Reflections on the 2026 OPT congress

Molecular Therapy: Nucleic Acids
Paloma H. Giangrande
doaj   +1 more source

Reported Pregnancy Outcomes after Biologic Therapy Exposure in Hidradenitis Suppurativa: A Systematic Review of Published Cases. [PDF]

Acta Derm Venereol
Sánchez-García V, De-Miguel-Balsa E, Ramos-Rincón JM, Belinchón-Romero I.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Tertiary lymphoid structures in chronic rhinosinusitis with nasal polyps: spatial organization, pathological functions, and implications for surgical strategy and biologic therapy. [PDF]

Front Immunol
Lin YS, Huang GJ, Lu BQ, Luo QP, Fan ZJ, Yang XS, Long CQ.   +6 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Biologic Therapy Is Associated with Faster Bone Union After the Sauvé-Kapandji Procedure in Patients with Rheumatoid Arthritis. [PDF]

Rheumatol Ther
Okabe H, Maeda K, Yamashita Y, Zenitani A, Nishizawa T, Yukawa M, Nishimura R, Bo H, Miyawaki T, Saito M.   +9 more
europepmc   +1 more source