Results 41 to 50 of about 8,290,554 (306)

Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Journal of Biomedical Sciences
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells ...
Yi-Fan Chen, F. Luh, Yuan-Soon Ho, Yen Yun   +3 more
semanticscholar   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Societal and personal financial burden of severe asthma and impact of biologic therapy: a 19-year nationwide cost analysis

BMJ Open Respiratory Research
Introduction Severe asthma incurs a financial burden on both patients and societies. However, little is known about the long-term financial burden and impact of biologic therapy.Methods All Danish adults initiating biologic therapy for severe asthma ...
Niels Steen Krogh, Anders Løkke, Rikke Ibsen, Johannes Martin Schmid, Charlotte Suppli Ulrik, Celeste Porsbjerg, Ole Hilberg, Susanne Hansen, Maria Bisgaard Borup, Sofie Lock Johansson, Barbara Bonnesen, Kjell E J Håkansson, Marianne Baastrup Søndergaard, Anne-Sofie Bjerrum, Anna von Bülow, Mogens Erik Kappel, Lycely Dongo, Roxana Vijdea, Linda Makowska Rasmussen   +18 more
doaj   +1 more source

Living with Ulcerative Colitis in Japan: Biologic Persistence and Health-Care Resource Use

Inflammatory Intestinal Diseases, 2021
Objective: The aim of the study was to improve understanding of adherence and persistence to biologics, and their association with health-care resource utilization (HCRU), in Japanese patients with moderate to severe ulcerative colitis (UC).
Danielle Bargo, Theo Tritton, Joseph C. Cappelleri, Marco DiBonaventura, Timothy W. Smith, Takanori Tsuchiya, Sean Gardiner, Irene Modesto, Tim Holbrook, Daniel Bluff, Taku Kobayashi   +10 more
doaj   +1 more source

Biological therapy of cancer [PDF]

Breast Cancer Research and Treatment, 1986
Interferons and monoclonal antibodies are among the most promising biological approaches to cancer treatment which have so far been investigated. Both natural and recombinant interferon-alpha preparations have shown activity in a number of trials in hematologic malignancies, even in previously treated patients; activity in solid tumors, however, has ...
openaire   +3 more sources

Melanoma Risk in Patients Treated With Biologic Therapy for Common Inflammatory Diseases: A Systematic Review and Meta-analysis.

JAMA dermatology, 2020
Importance Biologic therapies are widely prescribed immunomodulatory agents. There are concerns that compared with treatment with conventional systemic therapy, long-term biologic treatment for common immune-mediated inflammatory diseases, namely ...
Shamarke Esse, K. Mason, A. Green, R. Warren   +3 more
semanticscholar   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Severe Asthma Patients Experience and Satisfaction with Virtual Clinics during COVID-19 Period

Avicenna Journal of Medicine, 2021
Background Enforced social distancing (i.e., lockdowns) greatly facilitated control of coronavirus disease-19 (COVID-19). While access to hospitals was restricted, outpatient care continued remotely.
Mohammad Ayaz Khan, Rajendram Rajkumar, Mohammad Hammadi, Majed Al-Gamedi, Abdullah Al-Harbi, Hamdan Al-Jahdali   +5 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index.

JAMA cardiology, 2019
Importance Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably associated with luminal coronary plaque, but it is ...
Youssef Elnabawi, E. Oikonomou, A. Dey, J. Mancio, J. Rodante, Milena Aksentijevich, Harry Choi, A. Keel, Julie A Erb-Alvarez, H. Teague, A. Joshi, M. Playford, B. Lockshin, A. Choi, J. Gelfand, Marcus Y. Chen, D. Bluemke, C. Shirodaria, C. Antoniades, N. Mehta   +19 more
semanticscholar   +1 more source