Results 81 to 90 of about 7,643,336 (318)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1893
, 1894 Annual report of the Marine Biological Laboratory in Woods Hole. 1893.
Marine Biological Laboratory (Woods Hole MA)
core
Biological activities of Curcuma longa L.
Memorias do Instituto Oswaldo Cruz, 2001 There are several data in the literature indicating a great variety of pharmacological activities of Curcuma longa L. (Zingiberaceae), which exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacteria, antioxidant effects and nematocidal ...
CAC Araújo, LL Leon
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1903-1906
, 1907 https://hdl.handle.net/1912/21944Marine Biological Laboratory.
Marine Biological Laboratory (Woods Hole MA)
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1890
, 1890 Annual report of the Marine Biological Laboratory in Woods Hole. 1890.
Marine Biological Laboratory (Woods Hole MA)
core
Phytochemicals and Biological Activities of Species
Natural Product Communications, 2010 Gentiana , a cosmopolitan and important genus of the Gentianaceae family, comprises over 300 species distributed among the world. Phytochemical investigations on the title genus have led to characterization of almost two hundred secondary metabolites ...
Jun-Li Yang, Lei-Lei Liu, Yan-Ping Shi
doaj +1 more source
Biological activities of Salvia L species
Current Issues in Pharmacy and Medical Sciences, 2013 Salvia officinalis L. is one of the most widespread species, and because of this, is the most popular among other Salvia L. However, there are many other Salvia species with the long history of use in the treatment of a variety of disorders.
Tomasz Dziurzynski +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source