Results 121 to 130 of about 2,429,272 (299)

Race in the Life Sciences: An Empirical Assessment, 1950-2000 [PDF]

, 2015
The mainstream narrative regarding the evolution of race as an idea in the scientific community is that biological understandings of race dominated throughout the nineteenth and twentieth centuries up until World War II, after which a social ...
Darling, Katherine, Harris-Wai, Julie N., Keagy, Carolyn, Obasogie, Osagie K.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Editorial: Innovators in analytical chemistry

Frontiers in Chemistry, 2023
Camelia Bala, Nicole Jaffrezic-Renault, Gabriella Massolini, Giovanni Valenti   +3 more
doaj   +1 more source

Research on Red/Near-Infrared Fluorescent Carbon Dots Based on Different Carbon Sources and Solvents: Fluorescence Mechanism and Biological Applications

Nanomaterials
Fluorescent carbon dots, especially red/near-infrared-emitting CDs, are becoming increasingly important in the field of biomedicine. This article reviews the synthesis, fluorescence mechanisms, and biological applications of R/NIR-CDs, emphasizing the ...
Jun Song, Minghao Kang, Shujian Ji, Shuai Ye, Jiaqing Guo   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Quantitative ³¹P NMR Spectroscopy: Principles, Methodologies, and Applications in Phosphorus-Containing Compound Analysis

Applied Sciences
Nuclear magnetic resonance (NMR) spectroscopy is gaining prominence as a vital quantitative method for sample analysis, with significant progress being made in the investigation of heteronuclei like phosphorus, a key element in numerous physiological ...
Yaqin Liu, Lina Gao, Zeling Yu
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recent Advances in Calixarene-Based Fluorescent Sensors for Biological Applications

Sensors
Due to their structural features, macrocyclic compounds such as calixarenes, conjugated with a variety of fluorophores have led to the development of fluorescent probes for numerous applications. This review covers the recent advances (from 2009 to date)
Paula M. Marcos, Mário N. Berberan-Santos   +1 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Essential oils from Brazilian plants: A literature analysis of anti-inflammatory and antimalarial properties and in silico validation

Open Chemistry
Brazil’s rich biodiversity includes a plethora of native plants that are renowned for their medicinal and aromatic properties, many of which are particularly rich in essential oils (EOs). These plants have demonstrated biological activities, such as anti-
da Silva Marcilene Paiva, Ferreira Oberdan Oliveira, Costa Leonardo Souza, Botelho Anderson de Santana, Vilhena Karyme do Socorro de Souza, Zafar Muhammad, Kumar Ravendra, Mali Suraj N., Martins Luiza Helena da Silva, Horchani Mabrouk, Edziri Hayet, Cruz Jorddy Neves, de Oliveira Mozaniel Santana, Aguiar Eloisa Helena de Andrade   +13 more
doaj   +1 more source