Results 21 to 30 of about 4,740,594 (312)

Verapamil protects against hyperuricemia nephropathy through modulating TXNIP/NLRP3 inflammasome signaling pathway

陆军军医大学学报
Objective‍　‍To investigate the protective effect of verapamil on hyperuricemia nephropathy (HN) in mice through modulating TXNIP/NLRP3 inflammasome signaling pathway.
WANG Ting, WANG Ting, LI Li , ZHU Xin
doaj   +1 more source

Immunosensors for Assay of Toxic Biological Warfare Agents

Biosensors, 2023
An immunosensor for the assay of toxic biological warfare agents is a biosensor suitable for detecting hazardous substances such as aflatoxin, botulinum toxin, ricin, Shiga toxin, and others.
Miroslav Pohanka
doaj   +1 more source

Hematite Nanoparticles Synthesized by Green Route: Characterization, Anticancer and Antioxidant Activities

Inorganics
Recently, attention has shifted towards the green synthesis of nanoparticles using plant extracts rich in phytochemicals like phenols and flavonoids, offering an alternative method that avoids harmful chemicals and enables large-scale, low-cost ...
Safa Ezzine, Hela Ferjani, Oluwasayo E. Ogunjinmi, Damian C. Onwudiwe   +3 more
doaj   +1 more source

Sequential Sampling in Biological Assay [PDF]

Nature, 1953
IN an investigation relating to the isolation and purification of chorionic gonadotrophin from pregnancy urine, the following problem has arisen : “Does fraction A contain at least the amount X of chorionic gonadotrophin?” It was necessary to answer this question in the shortest possible time and to use as little material of A as possible.
E, BUKOVICS, F X, WOHLZOGEN
openaire   +2 more sources

A Novel Serum-Based Bioassay for Quantification of Cancer-Associated Transformation Activity: A Case–Control and Animal Study

Diagnostics
Background/Objectives: The detection of ovarian cancer remains challenging due to the lack of reliable serum biomarkers that reflect malignant transformation rather than mere tumor presence.
Aye Aye Khine, Hsuan-Shun Huang, Pao-Chu Chen, Chun-Shuo Hsu, Ying-Hsi Chen, Sung-Chao Chu, Tang-Yuan Chu   +6 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Mathematics of Biological Assay

Nature, 1944
IF in a biological assay the mean responses, y11, y12, of two groups of n animals to doses of a standard preparation the logarithms of which are x11, x12, are compared with the mean responses, y21, y22 to doses of the preparation under test the logarithms of which are x21, x22, it is often possible to express the relationship between dosage and ...
openaire   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Identification and Functional Characterization of a Novel SOX4 Mutation Predisposing to Coffin–Siris Syndromic Congenital Heart Disease

Children
Background/Objectives: Congenital heart disease (CHD) occurs in ~1% of all live neonates globally, rendering it the most prevalent developmental anomaly affecting humans; this condition confers substantial infant morbidity and mortality worldwide ...
Zi Yan, Bin-Bin Dong, Yan-Jie Li, Chen-Xi Yang, Ying-Jia Xu, Ri-Tai Huang, Xing-Yuan Liu, Yi-Qing Yang   +7 more
doaj   +1 more source