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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
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On the Biological Assay of Gastrin.
Acta Physiologica Scandinavica, 1947Summary.Samples of gastrin were assayed on cats in urethane‐chloralose anaesthesia in accordance with the technique of previous authors, Komarov AND Uvnäs.The secretory unit, S. U., i. e. the amount of gastrin producing 1 ml 1/10 n hydrochloric acid during one hour, was determined by injecting two different doses of the gastrin preparation ...
O, JALLING, J E, JORPES
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American Journal of Health-System Pharmacy, 2013
We read with concern the study by Goldspiel and colleagues,[1][1] which evaluated the stability of alemtuzumab after storage at room temperature. The authors used high-performance liquid chromatography (HPLC) to assess the loss of alemtuzumab over time.
Jill M, Kolesar, Lee, Vermeulen
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We read with concern the study by Goldspiel and colleagues,[1][1] which evaluated the stability of alemtuzumab after storage at room temperature. The authors used high-performance liquid chromatography (HPLC) to assess the loss of alemtuzumab over time.
Jill M, Kolesar, Lee, Vermeulen
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Journal of the American Pharmaceutical Association (Scientific ed.), 1949
It has been found that rodents are suitable test animals (or use in determining the potency of senna, and in the present work mice were used. The assay procedure described involves administering the preparation under test at three dosage levels selected with a view to producing positive laxative effects in approximately 25, 50, and 75 of three similar ...
L C, MILLER, E B, ALEXANDER
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It has been found that rodents are suitable test animals (or use in determining the potency of senna, and in the present work mice were used. The assay procedure described involves administering the preparation under test at three dosage levels selected with a view to producing positive laxative effects in approximately 25, 50, and 75 of three similar ...
L C, MILLER, E B, ALEXANDER
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A BIOLOGICAL ASSAY FOR CALCITONIN
Journal of Endocrinology, 1965SUMMARY (1) Calcitonin preparations from acetone-dried thyroid were administered to rats by various routes. (2) Intravenous administration, especially by infusion, produced a much greater fall in plasma calcium than s.c. or i.p. injection. (3) The log dose-effect curves after i.v.
M A, Kumar +6 more
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Biological assays for interferons
Journal of Immunological Methods, 2002Interferons (IFN) are potent biologically active proteins synthesised and secreted by somatic cells of all mammalian species. They have been well characterised, especially those of human origin, with respect to structure, biological activities, and clinical therapeutic effects.
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Materials Science and Engineering C: Materials for Biological Applications, 2019
Adenocarcinoma is the most lethal gynecologic tumor and treatment usually consists in surgery followed by chemotherapy. However, the chemotherapy benefits are eventually limited due to drug toxicity to normal tissues and cells, which cause several and ...
J. P. Abriata +8 more
semanticscholar +1 more source
Adenocarcinoma is the most lethal gynecologic tumor and treatment usually consists in surgery followed by chemotherapy. However, the chemotherapy benefits are eventually limited due to drug toxicity to normal tissues and cells, which cause several and ...
J. P. Abriata +8 more
semanticscholar +1 more source
A Sensitive Biologic Assay for ACTH
Endocrinology, 1962Fluorometric determination of corticosteroids in adrenal venous plasma of the acutely hypophysectomized rat has led to the development of 2 new techniques for the measurement of ACTH. The first, consisting of jugular injection of test material, with adrenal venous bleeding 5 minutes later, gives linearity of response to log doses of ACTH ranging from 0.
H S, LIPSCOMB, D H, NELSON
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Biologic Assay of Mercury Ointments*†
Journal of the American Pharmaceutical Association (Scientific ed.), 1947Using the storage of mercury in the kidney of the rat as a measure of cutaneous penetration, 8 official mercury ointments have been assayed. Mercury oleate and nitrate ointments showed the greatest penetration; calomel and yellow mercuric oxide showed the least.
E P, LAUG, E A, VOS, F M, KUNZE
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