Results 61 to 70 of about 9,490,238 (346)

Oxidative Stress and Antioxidants—A Critical Review on In Vitro Antioxidant Assays

Antioxidants, 2022
Antioxidants have been widely studied in the fields of biology, medicine, food, and nutrition sciences. There has been extensive work on developing assays for foods and biological systems.
Raghavendhar R. Kotha, F. S. Tareq, E. Yıldız, Devanand L. Luthria   +3 more
semanticscholar   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

A COMPARATIVE BIOLOGICAL STUDY, RELATED TO THE THERAPEUTICALLY EFFECTS OF PAN BREAD PROVIDED WITH SOME NATURAL FOODSTUFFS UTILIZED, ON THE EXPERIMENTAL RATS [PDF]

Journal of Food and Dairy Sciences, 2008
To understand the link between some nutritional diseases and different natural sources of carbohydrates, formulated pan bread (control) was prepared and investigated in a comparative study with other formulae in which an acceptable amount of foodstuffs ...
Mona Doeidar, Ebtesam Mohamed, M. Saleh
doaj   +1 more source

Enzymatic Synthesis and Antimicrobial Activity of Oligomer Analogues of Medicinal Biopolymers from Comfrey and Other Species of the Boraginaceae Family

Pharmaceutics, 2022
This study reports the first enzymatic synthesis leading to several oligomer analogues of poly[3-(3,4-dihydroxyphenyl)glyceric acid]. This biopolymer, extracted from plants of the Boraginaceae family has shown a wide spectrum of pharmacological ...
Maia Merlani, Dieter M. Scheibel, Vakhtang Barbakadze, Lali Gogilashvili, Lela Amiranashvili, Athina Geronikaki, Valentina Catania, Domenico Schillaci, Giuseppe Gallo, Ivan Gitsov   +9 more
doaj   +1 more source

Repurposing high-throughput image assays enables biological activity prediction for drug discovery

Cell Chemical Biology, 2018
SUMMARY In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly important physiologically relevant model systems that require primary cells, organoids,
J. Simm, G. Klambauer, A. Arany, M. Steijaert, J. Wegner, Emmanuel Gustin, V. Chupakhin, Yolanda T. Chong, J. Vialard, P. Buijnsters, I. Velter, A. Vapirev, Shantanu Singh, Anne E Carpenter, Roel Wuyts, S. Hochreiter, Y. Moreau, H. Ceulemans   +17 more
semanticscholar   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Applied Biological Control in Brazil: From Laboratory Assays to Field Application

Journal of Insect Science, 2019
Brazil has a long history of the use of biological control (BC) of pests. The first attempt to use parasitoids was reported in the 1930s, and the first successful case dates to 1967.
José Roberto Postali Parra, A. Coelho
semanticscholar   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity

WIREs Computational Molecular Science, 2018
Biomolecular simulation is increasingly central to understanding and designing biological molecules and their interactions. Detailed, physics‐based simulation methods are demonstrating rapidly growing impact in areas as diverse as biocatalysis, drug ...
D. Huggins, P. Biggin, M. A. Dämgen, J. Essex, Sarah A. Harris, Richard H. Henchman, S. Khalid, Antonija Kuzmanic, C. Laughton, J. Michel, A. Mulholland, E. Rosta, M. Sansom, M. W. van der Kamp   +13 more
semanticscholar   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source