Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. [PDF]
Drosophila CRYPTOCHROME (dCRY) mediates electrophysiological depolarization and circadian clock resetting in response to blue or ultraviolet (UV) light.
Au, David D+5 more
core +1 more source
The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription [PDF]
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
A Alboresi+88 more
core +5 more sources
Biological Clocks and Ventricular Tachyarrhythmias
Sudden cardiac death (SCD) due to sustained ventricular tachyarrhythmias (VTA) remains a major public health problem because of poor understanding of the mechanisms. Initiation of VTA in animal models and in patients usually requires intense metabolic or electrical stimuli not often observed ...
openaire +3 more sources
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source
Multi-tissue DNA methylation age predictor in mouse
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs+7 more
doaj +1 more source
Is Phytomelatonin a New Plant Hormone?
Melatonin (N-acetyl-5-methoxytryptamine) is of particular importance as a chronobiological hormone in mammals, acting as a signal of darkness that provides information to the brain and peripheral organs.
Marino B. Arnao, Josefa Hernández-Ruiz
doaj +1 more source
Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao+8 more
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley +1 more source
Mitochondrial differentiation, introgression and phylogeny of species in the Tegenaria atrica group (Araneae, Agelenidae) [PDF]
The relationships between the three members of the Tegenaria atrica group (T. atrica, T. saeva and T. gigantea) were examined with DNA sequence data from mitochondrial CO1, 16S rRNA, tRNAleu(CUN) and ND1 genes.
Barton+55 more
core +1 more source