Results 101 to 110 of about 261,145 (320)

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

The Possible Role of Extra-ocular Photoreceptors in the Entrainment of Lobster Circadian Rhythms to Light:Dark Cycles [PDF]

, 2013
The American lobster, Homarus americanus, is a decapod crustacean whose daily nocturnal rhythms of activity are driven, in part, by an internal biological clock. While this circadian clock is capable of producing a rhythm of approximately 24 hours on its
McKinney, Sara A
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

eLife, 2016
In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a “segmentation clock”. This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression patterns ...
Alexis B Webb, Iván M Lengyel, David J Jörg, Guillaume Valentin, Frank Jülicher, Luis G Morelli, Andrew C Oates   +6 more
doaj   +1 more source

Orchestrated transcription of biological processes in the marine picoeukaryote Ostreococcus exposed to light/dark cycles [PDF]

, 2010
Background: Picoeukaryotes represent an important, yet poorly characterized component of marine phytoplankton. The recent genome availability for two species of Ostreococcus and Micromonas has led to the emergence of picophytoplankton comparative ...
Bouget, François-Yves, Bouvet, Régis, Corellou, Florence, Jesson, Béline, Liverani, Silvia, Monnier, Annabelle, Mosser, Jean, Smith, J. Q.   +7 more
core   +7 more sources

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System

Frontiers in Neuroscience, 2019
Exposure to light at night (LAN) has been associated with serious pathologies, including obesity, diabetes and cancer. Recently we showed that 2 h of LAN impaired glucose tolerance in rats. Several studies have suggested that the autonomic nervous system
Anne-Loes Opperhuizen, Anne-Loes Opperhuizen, Ewout Foppen, Martijs Jonker, Paul Wackers, Martijn van Faassen, Michel van Weeghel, Linda van Kerkhof, Eric Fliers, Andries Kalsbeek, Andries Kalsbeek, Andries Kalsbeek   +11 more
doaj   +1 more source

Depolarization of the intergeniculate leaflet neurons by serotonin : in vitro study [PDF]

, 2013
The intergeniculate leaflet of the thalamus (IGL) is a part of the mammalian biological clock which integrates photic and non-photic information and conveys it to the master biological clock - suprachiasmatic nuclei (SCN).
Chrobok, Łukasz, Lewandowski, Marian, Palus-Chramiec, Katarzyna   +2 more
core  

Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri [PDF]

, 2010
The development of systemic approaches in biology has put emphasis on identifying genetic modules whose behavior can be modeled accurately so as to gain insight into their structure and function.
A Goldbeter, A Goldbeter, Albert Goldbeter, AN Dodd, Benjamin Pfeuty, C Courties, C Troein, CS Pittendrigh, D Alabadi, D Gonze, D Rand, DA Rand, DB Forger, DGM Beersma, E Derelle, E Elowitz, E Hairer, F Corellou, F Geier, Florence Corellou, François-Yves Bouget, G Kurosawa, G Kurosawa, G Tiana, J Guckenheimer, J Moré, J Stricker, J Tomita, JC Leloup, JCW Locke, JCW Locke, JCW Locke, JD Salazar, L Ashall, L Rensing, LK Bognar, M Elowitz, M Merrow, M Moulager, MA Kramer, Marc Lefranc, MJ Chretiennot-Dinet, MN Zeilinger, N Barkai, NA Cookson, P Francois, P François, PE Morant, Pierre-Emmanuel Morant, Quentin Thommen, R Toth, S Panda, SR Taylor, TS Gardner, U Alon, W Mather, WW Wong, Y Ouyang, Y Shav-Tal   +58 more
core   +5 more sources