Results 31 to 40 of about 261,145 (320)
Accumulating evidence suggests that astrocytes, the abundant cell type in the central nervous system (CNS), play a critical role in maintaining the immune response after cerebral infarction, regulating the blood-brain barrier (BBB), providing nutrients ...
Yuxing Zhang+11 more
doaj +1 more source
Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis [PDF]
Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors ...
Anderson, David J.+6 more
core +1 more source
Computing with biological switches and clocks [PDF]
The complex dynamics of biological systems is primarily driven by molecular interactions that underpin the regulatory networks of cells. These networks typically contain positive and negative feedback loops, which are responsible for switch-like and oscillatory dynamics, respectively.
Andrew Phillips+8 more
openaire +5 more sources
We recently found that the mRNA expression of Slc25a25, a Ca2+-sensitive ATP carrier in the inner mitochondrial membrane, fluctuates in a circadian manner in mouse skeletal muscle.
Reiko Nakao+2 more
doaj +1 more source
Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core +2 more sources
Research progress of biological clock in regulation of tumor development [PDF]
Biological clock is a physiological controlling system with self-regulating functions. There is a close relationship between biological clock disorders and the occurrence of tumors, but underlying mechanism has not yet been elucidated.
GAO Dong-xiao, LIU Dan, GUO Qiang, LUO Ying, LIU Jing
doaj
Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E+5 more
core +2 more sources
Role of circadian gene Clock during differentiation of mouse pluripotent stem cells
Biological rhythms controlled by the circadian clock are absent in embryonic stem cells (ESCs). However, they start to develop during the differentiation of pluripotent ESCs to downstream cells.
Chao Lu+7 more
doaj +1 more source
CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9
Background Clock circadian regulator (CLOCK) is a core factor of the mammalian biological clock system in regulating female fertility and ovarian physiology.
Liang Huang+9 more
doaj +1 more source
The circadian rhythm is a physiological phenomenon that occurs in various organisms with a cycle of about 24 hours. Light is one of the important environmental factors affecting biological rhythm.
He Ma+14 more
doaj +1 more source