Results 61 to 70 of about 3,185,463 (348)

Evaluation of pediatric epigenetic clocks across multiple tissues

Clinical Epigenetics, 2023
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. Camargo, Nicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, on behalf of program collaborators for Environmental influences on Child Health Outcomes   +28 more
doaj   +1 more source

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]

, 2008
In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa, Chabot, Christopher C., Watson, Winsor H., III   +2 more
core   +3 more sources

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

bioRxiv, 2020
Human DNA-methylation data have been used to develop biomarkers of ageing - referred to ‘epigenetic clocks’ - that have been widely used to identify differences between chronological age and biological age in health and disease including ...
Gemma L Shireby, Jonathan P. Davies, P. Francis, Joe Burrage, Emma M. Walker, Grant W. A. Neilson, Aisha Dahir, Alan J. Thomas, S. Love, Rebecca G. Smith, K. Lunnon, M. Kumari, L. Schalkwyk, K. Morgan, K. Brookes, E. Hannon, J. Mill   +16 more
semanticscholar   +1 more source

Identification of the Molecular Clockwork of the Oyster Crassostrea gigas. [PDF]

PLoS ONE, 2017
Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology.
Mickael Perrigault, Damien Tran
doaj   +1 more source

Inverse relationship between genetic diversity and epigenetic complexity [PDF]

, 2008
Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core   +3 more sources

Neurotransmitters of the suprachiasmatic nuclei

Journal of Circadian Rhythms, 2006
There has been extensive research in the recent past looking into the molecular basis and mechanisms of the biological clock, situated in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus.
Reghunandanan Rajalaxmy, Reghunandanan Vallath   +1 more
doaj   +1 more source

Diurnal Rhythms in Neurexins Transcripts and Inhibitory/Excitatory Synapse Scaffold Proteins in the Biological Clock

PLoS ONE, 2012
The neurexin genes (NRXN1/2/3) encode two families (α and β) of highly polymorphic presynaptic proteins that are involved in excitatory/inhibitory synaptic balance.
Mika Shapiro-Reznik, Anje Jilg, Hadas Lerner, David J. Earnest, Nava Zisapel   +4 more
openalex   +3 more sources

Dimerization and nuclear entry of mPER proteins in mammalian cells [PDF]

, 2000
Nuclear entry of circadian oscillatory gene products is a key step for the generation of a 24-hr cycle of the biological clock. We have examined nuclear import of clock proteins of the mammalian period gene family and the effect of ...
Yagita, K. (Kazuhiro), Yamaguchi, S., Tamanini, F. (Filippo), Yasui, A. (Akira), Loros, J.J., Dunlap, J.C., Okamura, H. (Hitoshi), Hoeijmakers, J.H.J. (Jan), Horst, G.T.J. (Gijsbertus) van der   +8 more
core   +8 more sources

Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives

Marine Drugs
Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions.
Youngji Han, Dong Hyun Kim, Seung Pil Pack   +2 more
doaj   +1 more source

Limited water stress modulates expression of circadian clock genes in Brachypodium distachyon roots

Scientific Reports, 2023
Organisms have evolved a circadian clock for the precise timing of their biological processes. Studies primarily on model dicots have shown the complexity of the inner timekeeper responsible for maintaining circadian oscillation in plants and have ...
Magdolna Gombos, Nóra Hapek, László Kozma-Bognár, Gábor Grezal, Zoltán Zombori, Edina Kiss, János Györgyey   +6 more
doaj   +1 more source