Results 71 to 80 of about 3,185,463 (348)

Biological clock: Biological clocks may modulate drug addiction [PDF]

open access: yesEuropean Journal of Human Genetics, 2005
A recent study by McClung's group (2005),1 expanding on an earlier report,2 provides mechanistic insight to the timekeeper gene, Clock, which may regulate dopaminergic transmission and cocaine reward. This work provides further evidence that cocaine-induced effects have circadian influences.
Vadim Yuferov   +2 more
openaire   +1 more source

The Tibetan medicine Zuotai influences clock gene expression in the liver of mice [PDF]

open access: yesPeerJ, 2016
Background. The circadian clock is involved in drug metabolism, efficacy and toxicity. Drugs could in turn affect the biological clock as a mechanism of their actions.
Huan Li   +4 more
doaj   +2 more sources

Sensitization of GSH synthesis by curcumin curtails acrolein-induced alveolar epithelial apoptosis via Keap1 cysteine conjugation: A randomized controlled trial and experimental animal model of pneumonitis

open access: yesJournal of Advanced Research, 2023
Introduction: Epidemiological studies have reported an association between exposures to ambient air pollution and respiratory diseases, including chronic obstructive pulmonary disease (COPD).
Eun Hee Jo   +20 more
doaj   +1 more source

Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off

open access: yesInternational Journal of Molecular Sciences, 2016
The circadian biological clock is essentially based on the light/dark cycle. Some people working with shift schedules cannot adjust their sleep/wake cycle to the light/dark cycle, and this may result in alterations of the circadian biological clock. This
M. Bracci   +11 more
semanticscholar   +1 more source

How to Synchronize Biological Clocks [PDF]

open access: yesJournal of Computational Biology, 2009
This paper is concerned with a novel algorithm to study networks of biological clocks. A new set of conditions is established that can be used to verify whether an existing network synchronizes or to give guidelines to construct a new synthetic network of biological oscillators that synchronize.
G. Russo, DI BERNARDO, MARIO
openaire   +5 more sources

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort [PDF]

open access: yes, 2019
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation ...
Banszerus, Verena L.   +4 more
core   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis   +9 more
wiley   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale   +6 more
wiley   +1 more source

Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs.

open access: yesPLoS ONE, 2019
The use of emerging tobacco products, such as waterpipe or hookah and electronic cigarettes (e-cigs), has gained significant popularity and are promoted as safer alternatives to conventional cigarettes.
Naushad Ahmad Khan   +5 more
doaj   +1 more source

The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia

open access: yesJournal of Experimental & Clinical Cancer Research, 2023
Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with asymmetrically enriched leukemia initiating cell (LIC) activity.
Emanuele Murgo   +15 more
doaj   +1 more source

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