Results 221 to 230 of about 12,079,690 (308)

Unlocking biodiversity data with robotic imaging and AI-driven transcription of natural history collections. [PDF]

Sci Adv
Johnson CA, Willigan EM, Hwang EY, Austin PM, Chang KL, Daly P, Davis A, Gonzalez JM, Kao CN, Mifsud IEJ, Miller KA, Nicolescu M, Ruiz AM, Ruo EY, Schwartzman JL, Seeman AB, Stenzel J, Zurita NC, Berniker LF, Rodríguez E.   +19 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Seasonal metabolomics and antibacterial activity of <i>Abutilon pannosum</i> reveal positive interaction with the lytic phage CF01 against <i>Escherichia coli</i> O157:H7 (strain 161-84). [PDF]

Front Microbiol
Alarjani KM, Sallam O, Osaili TM, Bekliz M, Alhaj Hamoud Y, Elnaggar A, El-Keblawy A.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Into the unknown: a literature review of helminths of amphibians and reptiles in Mesoamerica. [PDF]

Parasit Vectors
Estrada-Pull T, Boza-Oviedo E, Alfaro-Segura P, Mendoza-Roldan JA, Solano-Barquero A, Otranto D, Rojas A.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

From Knowledge to Action: Next Steps for the Natural Science Collections Community. [PDF]

Bioscience
Ellwood ER, Nelson G, Zimkus B, Bates J, Cook JA, Pandey J, Sessa E, Borths M, Goodwin J, Jennings D, Soltis PS.   +10 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Hidden pesticidal diversity within the <i>Bacillus cereus</i> group: expanding the concept beyond <i>Bacillus thuringiensis</i>. [PDF]

Sustain Microbiol
Sauka DH, Palma L.
europepmc   +1 more source