Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Sweetpotato whitefly: prospects for biological control
California Agriculture, 1992 The damage to desert agricultural crops in Southern California and Arizona in fall-winter 1991 by the sweetpotato whitefly, Bemisia tabaci (Gennadius) is unprecedented in the history of the South west.
M Parrelta +4 more
doaj
Biological control of Rubus alceifolius (Rosaceae) in La Reunion Island (Indian Ocean): from investigations on the plant to the release of the biological control agent Cibdela janthina (Argidae) [PDF]
, 2013 The giant bramble (Rubus alceifolius Poir.: Rosaceae), native to Southeast Asia, is one of the most invasive plants in La Reunion. A ten year research program was launched in 1997 with three components: i) genetic diversity, ii) development strategy, and
Baret, Stéphane +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Biological control of variegated grape leafhopper
California Agriculture, 1987 Two look-alike imported biotypes of a parasitic wasp are being tested against the variegated grape leafhopper in the San Joaquin Valley.
C Pickett +3 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Biological control of pests in protected cultivation: implementation in Latin America and successes in Europe [PDF]
The area with greenhouse crops is estimated to be around 40,000 hectares in Latin America, of which approximately 60% is occupied with ornamentals. Several pests are responsible for losses in yield or quality of greenhouse crops production and pest ...
Bueno, V.H.P., Lenteren, J.C., van
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Biological Control of Weeds: Theory and Practical Application [PDF]
Crop Production/Industries,
Julien, Mic H., White, Graham
core +1 more source
Biological Agents of Bioremediation: A Concise Review [PDF]
, 2015 Due to intensive agriculture, rapid industrialization and anthropogenic activities have caused environmental pollution, land degradation and increased pressure on the natural resources and contributing to their adulteration.
Biswas, Karabi
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