Results 181 to 190 of about 29,021,689 (318)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1961

, 1960
Annual report of the Marine Biological Laboratory in Woods Hole. 1961.
Marine Biological Laboratory (Woods Hole MA)
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Longitudinal big biological data in the AI era. [PDF]

Mol Syst Biol
Mardinoglu A, Turkez H, Shong M, Srinivasulu VP, Nielsen J, Palsson BO, Hood L, Uhlen M.   +7 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1915

, 1912
Annual report of the Marine Biological Laboratory in Woods Hole. 1915.
Marine Biological Laboratory (Woods Hole MA)
core  

The Statistical Significance of Biological Data [PDF]

BMJ, 1954
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A comprehensive database for biological data derived from sewage in five European cities. [PDF]

Database (Oxford)
Becsei Á, Munk P, Fuschi A, Otani S, Stéger J, Visontai D, Papp K, Brinch C, Kant R, Weinstein I, Vapalahti O, de Graaf M, Schapendonk CME, Roelfsema J, van den Beld M, Pijnacker R, Franz E, Alba P, Battisti A, De Cesare A, Indio V, Troja F, Sironen T, Oliveri C, Pasquali F, Liachko I, Auch B, O'Cathail C, Bányai K, Makó M, Pollner P, Koopmans M, Csabai I, Remondini D, Aarestrup FM.   +34 more
europepmc   +1 more source

KMD clustering: robust general-purpose clustering of biological data. [PDF]

Commun Biol, 2023
Zelig A, Kariti H, Kaplan N.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source