Results 41 to 50 of about 259,966 (297)

Solid Dispersions of Biologically Active Substances

, 2020
Due to the rapid development of nanotechnologies, materials, in particular , solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on ...
openaire   +2 more sources

Controlled radical polymerization in dispersed systems for biological applications [PDF]

Progress in Polymer Science, 2020
Polymeric nanoparticles show great promise in a range of biomedical applications, improving pharmacokinetic properties, dose requirements and immune response in drug delivery and bioimaging. Common synthesis techniques such as self-assembly, while prevalent, are unscalable and require the use of organic solvents, or extensive purification. In contrast,
Gurnani, Pratik, Perrier, Sébastien
openaire   +1 more source

More rapid climate change promotes evolutionary rescue through selection for increased dispersal distance [PDF]

, 2012
Acknowledgements This research was funded by FWO projects G.0057.09 to DB and JB, and G.0610.11 to DB, JB and RS.
Boeye, Jeroen, Bonte, Dries, Stoks, Robby, Travis, Justin M. J.   +3 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Personality, density and habitat drive the dispersal of invasive crayfish

Scientific Reports, 2022
There is increasing evidence that personality traits may drive dispersal patterns of animals, including invasive species. We investigated, using the widespread signal crayfish Pacifastacus leniusculus as a model invasive species, whether effects of ...
Shams M. Galib, Jingrui Sun, Sean D. Twiss, Martyn C. Lucas   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A trait-based approach for predicting species responses to environmental change from sparse data : how well might terrestrial mammals track climate change? [PDF]

, 2016
Acknowledgements LS was supported by two STSMs by the COST Action ES1101 ”Harmonising Global Biodiversity Modelling“ (Harmbio), supported by COST (European Cooperation in Science and Technology).
Bocedi, Greta, Bullock, James M., Cornulier, Thomas, Hodgson, Jenny A., Palmer, Stephen C. F., Santini, Luca, Travis, Justin M. J., White, Steven M.   +7 more
core   +2 more sources

On fibre dispersion modelling of soft biological tissues: a review [PDF]

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2019
Collagen fibres within fibrous soft biological tissues such as artery walls, cartilage, myocardiums, corneas and heart valves are responsible for their anisotropic mechanical behaviour. It has recently been recognized that the dispersed orientation of these fibres has a significant effect on the mechanical response of the tissues.
Gerhard A. Holzapfel, Ray W. Ogden, Selda Sherifova   +2 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source