Results 281 to 290 of about 2,108,914 (342)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Different chromatographic techniques and recent advancements for biomedical and pharmaceutical applications. [PDF]

North Clin Istanb
Coskun O, Akbarzadeh S, Guncer B.
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Ligase-mediated programmable genomic integration (L-PGI). [PDF]

Nat Commun
Nan AX, Chickering M, Bartolome CL, Shadija N, Li D, Estes BJG, Stetina JV, Li W, Andresen J, Molugu K, Amunugama R, Fang M, Bai C, Wang J, Norouzi D, Cochrane JC, Gatlin JT, Dunyak MT, Kumar S, Chavez L, Seth A, Halperin S, Finn JD, Xie J.   +23 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Periodic asymmetric field enhances electrofusion of nanoscale lipid systems. [PDF]

Nat Commun
Wu H, Liu WC, Wu X, Li Z, Zhang J, Wang J, Zhu Q, Zhang J, Dong K, Lin R, Hu H, Zeng J, Wu J, Li K, Nan K, Zhang T, Gao J.   +16 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Directed evolution on compact landing pads yields highly efficient recombinases for large DNA integration. [PDF]

Nucleic Acids Res
Kim H, Kang HG, Oh Y, Lee WJ, Lee Y, Kim EK, Nam KH, Lee DS, Lee SH, Sim BW.   +9 more
europepmc   +1 more source

Productivity and Biological Efficiency Indices of Sesamum + Cowpea Intercropping System in Response to Row Ratio and Nutrient Management

openalex   +1 more source

Biogenic Approaches to Metal Nanoparticle Synthesis and Their Application in Biotechnology. [PDF]

Plants (Basel)
Yugay Y, Shkryl Y.
europepmc   +1 more source