Results 171 to 180 of about 7,103,771 (354)

Host traits and environmental variation shape gut microbiota diversity in wild threespine stickleback

Animal Microbiome
Background Despite the growing recognition of the importance of gut microbiota in host ecology and evolution, our understanding of the relative contributions of host-associated and environmental factors shaping gut microbiota composition within and ...
Andreas Härer, Emma Kurstjens, Diana J. Rennison   +2 more
doaj   +1 more source

Stability-based sorting: The forgotten process behind (not only) biological evolution

bioRxiv, 2017
J. Flegr, J. Toman
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Modeling the Evolution of Biological Neural Networks Based on Caenorhabditis elegans Connectomes across Development [PDF]

, 2022
Hongfei Zhao, Zhiguo Shi, Zhefeng Gong, Shibo He   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Self-Organization of the Biological Evolution. [PDF]

Genes (Basel), 2019
Arber W.
europepmc   +1 more source

Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus [PDF]

, 2019
Vincent Houé, Gaëlle Gabiane, Catherine Dauga, Marie Suez, Yoann Madec, Laurence Mousson, Michele Marconcini, Pei‐Shi Yen, Xavier de Lamballerie, Mariangela Bonizzoni, Anna‐Bella Failloux   +10 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

HOMINID BIOLOGICAL EVOLUTION [PDF]

Evolution, 1977
Arthur E. Spiess, Russell H. Tuttle, Karl W. Butzer, Glynn Ll. Isaac   +3 more
openaire   +2 more sources

Rapid evolution of symbiont‐mediated resistance compromises biological control of aphids by parasitoids [PDF]

, 2017
Heidi Käch, Hugo Mathé‐Hubert, Alice B. Dennis, Christoph Vorburger   +3 more
openalex   +1 more source