Results 261 to 270 of about 5,611,755 (345)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

LC-MS/MS and LC-PDA Methods for Robust Determination of Glycerol Phenylbutyrate in Biological Fluids and High-Resolution Mass Spectrometric Identification of Forced Degradation Product and Its Whiteness. [PDF]

ACS Omega
Levent S, Elriş A, Avcı H, Uzunoğlu ÜE, Özcan S, Can NÖ.   +5 more
europepmc   +1 more source

Surface Oxygen Deficiency Enabled Spontaneous Antiprotein Fouling in WO₃ Nanosheets for Biosensing in Biological Fluids. [PDF]

Anal Chem
He G, Dong T, Yang Z, Stokke BRT, Jiang Z.   +4 more
europepmc   +1 more source

Optimization of Binding Buffer Composition (Polyethylene Glycol, Sodium Chloride and pH) for Extraction of DNA from Biological Fluids Using Polyethyleneimine Functionalized Iron Oxide Nanoparticle-Based Method. [PDF]

Nanotechnol Sci Appl
Khan I, Kaushik G, Verma C, Vashishtha R, Kumar V.   +4 more
europepmc   +1 more source

Surface Modifications of Nanoparticles for Stability in Biological Fluids

Materials, 2018
Due to the high surface: volume ratio and the extraordinary properties arising from the nanoscale (optical, electric, magnetic, etc.), nanoparticles (NPs) are excellent candidates for multiple applications.
Luca Guerrini, Ramon A Alvarez-Puebla, Nicolas Pazos-Pérez   +2 more
exaly   +3 more sources

Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres

Critical Reviews in Toxicology, 2021
The use of simulated biological fluids (SBFs) is a promising in vitro technique to better understand the release mechanisms and possible in vivo behaviour of materials, including fibres, metal-containing particles and nanomaterials.
Humphrey H P Yiu, Matthew Boyles
exaly   +2 more sources

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Bionic Engineered Protein Coating Boosting Anti‐Biofouling in Complex Biological Fluids

Advances in Materials, 2022
Implantable medical devices have been widely applied in diagnostics, therapeutics, organ restoration, and other biomedical areas, but often suffer from dysfunction and infections due to irreversible biofouling. Inspired by the self‐defensive “vine‐thorn”
Ziqian Zhao, Mingfei Pan, Chenyu Qiao, Li Xiang, Xiong Liu, Wenshuai Yang, Xing-Zhen Chen, Hongbo Zeng   +7 more
semanticscholar   +1 more source

Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

Espert Review of Proteomics, 2022
Introduction Biological fluids are routine samples for diagnostic testing and monitoring. Blood samples are typically measured because of their moderate invasive collection and high information content on health and disease.
L. Dayon, Ornella Cominetti, M. Affolter
semanticscholar   +1 more source

Segregation in desiccated sessile drops of biological fluids

European Physical Journal E, 2007
It is shown here that concurrence between advection and diffusion in a drying sessile drop of a biological fluid can produce spatial redistribution of albumen and salt.
Yuri Yu Tarasevich
exaly   +2 more sources