Results 31 to 40 of about 10,240,076 (319)

Biological Functions and Metabolism of Oleoylethanolamide

Lipids, 2008
AbstractThe present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non‐genomic effect mediated through peroxisome proliferator‐activated receptor alpha (PPAR‐α) and transient receptor ...
Thabuis, Clémentine, Tissot-Favre, Delphine, Bezelgues, Jean-Baptiste, Martin, Jean-Charles, Cruz-Hernandez, Cristina, Dionisi, Fabiola, Destaillats, Frédéric   +6 more
openaire   +5 more sources

Computational design of 3C-like protease substrate peptide for modular detection of protease activity of coronavirus

Engineering in Life Sciences
The severity of the recent Coronavirus Disease 2019 pandemic stresses the importance of analytical and biosensor research aimed at determining and curbing disease severity. It demanded an easy-to-adapt method to reflect the infectivity of viruses.
Yuqi Han, Wei Guo, Long Sun, Siyu Du, Feifei Li, Tao Wang, Cheng Zhu   +6 more
doaj   +1 more source

Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin

Nature Communications, 2022
High-crystallinity poly(ethylene terephthalate) is a major recycling challenge. Here, the authors show an engineered whole-cell biocatalyst showing adhesive hydrophobin and PETase on the surface of cells, for biodegradation of PET.
Zhuozhi Chen, Rongdi Duan, Yunjie Xiao, Yi Wei, Hanxiao Zhang, Xinzhao Sun, Shen Wang, Yingying Cheng, Xue Wang, Shanwei Tong, Yunxiao Yao, Cheng Zhu, Haitao Yang, Yanyan Wang, Zefang Wang   +14 more
doaj   +1 more source

3D Printed Nanocellulose Scaffolds as a Cancer Cell Culture Model System

Bioengineering, 2021
Current conventional cancer drug screening models based on two-dimensional (2D) cell culture have several flaws and there is a large need of more in vivo mimicking preclinical drug screening platforms.
Jennifer Rosendahl, Andreas Svanström, Mattias Berglin, Sarunas Petronis, Yalda Bogestål, Patrik Stenlund, Simon Standoft, Anders Ståhlberg, Göran Landberg, Gary Chinga-Carrasco, Joakim Håkansson   +10 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Molecular Packing in Network-Forming Collagens

The Scientific World Journal, 2003
Collagen is the most abundant protein among vertebrates and occurs in virtually all multicellular animals. Collagen molecules are classified into 21 different types and differ in their sequence, weight, structure, and function, but they can be broadly ...
Carlo Knupp, John M. Squire
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

The structural basis of translational control by eIF2 phosphorylation

Nature Communications, 2019
During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B.
Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt   +6 more
doaj   +1 more source

Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?

Biomolecules, 2022
Eukaryotic cells have developed a complex circuitry of signalling molecules which monitor changes in their intra- and extracellular environments. One of the most widely studied signalling pathways is the highly conserved cyclic AMP (cAMP)/protein kinase ...
Declan R. Creamer, Simon J. Hubbard, Mark P. Ashe, Chris M. Grant   +3 more
doaj   +1 more source