Results 41 to 50 of about 576,415 (259)

A multiscale analysis of nutrient transport and biological tissue growth in vitro [PDF]

, 2014
In this paper, we consider the derivation of macroscopic equations appropriate to describe the growth of biological tissue, employing a multiple-scale homogenisation method to accommodate explicitly the influence of the underlying microscale structure of
Nelson, M. R., Byrne, H. M., Nelson, Martin, R., El Haj, A. J., Nelson, MR, O'Dea, R. D., Waters, S. L., El Haj, AJ, O'Dea, Reuben D., O'Dea, RD, Byrne, HM, El Haj, A., Waters, SL, Byrne, Helen M., Waters, Sarah L.   +14 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Definition and establishment of biological exposure limits of pesticides for the interpretation of biological monitoring data

, 2020
Pesticides are among the most employed synthetic chemicals, and for which there, is the largest database of chemical and toxicological information that allows establishing health-based exposure limits.
Stefan Mandić-Rajčević, Mandić-Rajčević, Stefan, Colosio, Claudio, Rubino, Federico Maria, Federico Maria Rubino, Claudio Colosio   +5 more
core   +1 more source

Kinetic limits for pair-interaction driven master equations and biological swarm models [PDF]

, 2013
International audienceWe consider a class of stochastic processes modeling binary interactions in an N-particle system. Examples of such systems can be found in the modeling of biological swarms. They lead to the definition of a class of master equations
Wennberg, Bernt, Degond, P, Degond, Pierre, Carlen, E.,, Wennberg, Bernt,, Wennberg, B, Carlen, E., Degond, P., Degond, P.,, Carlen, Eric, Carlen, E   +10 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

BIOMECHANICAL AND BIOLOGICAL LIMITS IN ARTISTIC GYMNASTICS

, 2008
Artistic gymnastics increased excessively the difficulty of single elements and entire routines in the last decades. Biomechanical and biological factors related the performance enhancement indicate that the potential of the musculo-skeletal system seems
Brüggemann, Gert Peter
core