Results 51 to 60 of about 576,415 (259)
Local and global limits on visual processing in schizophrenia. [PDF]
, 2015 Schizophrenia has been linked to impaired performance on a range of visual processing tasks (e.g. detection of coherent motion and contour detection).
Steven C. Dakin +33 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biological transport: membrane channels, a white noise flashing ratchet model
, 2008 Màster en Biofísica Part I, curs 2007-2008. Part II la trobareu a: http://hdl.handle.net/2445/6722We explore biological transport across membrane channels from a physical point of view.
Gómez Orlandi, Javier
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quantifying the potential for sexual dimorphism using upper limits on Bateman gradients
, 2008 Sex differences in the correlation between number of offspring and number of mates likely drive much of the evolution of morphological and behavioral sexual differences. These correlations have traditionally been represented by slopes from regressions of
Lorch, Patrick D +2 more
core +1 more source
A Review on Theory and Modelling of Nanomechanical Sensors for Biological Applications
, 2021 Over the last decades, nanomechanical sensors have received significant attention from the scientific community, as they find plenty of applications in many different research fields, ranging from fundamental physics to clinical diagnosis.
Ramos Vega, Daniel +11 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FIGURE 3 in The limits of understanding in biological systematics
, 2012 FIGURE 3. Relations between the (A) premises and (B) conclusion of an abductive inference to phylogenetic hypotheses, and (C) the direct indication of the abductive support for those hypotheses.
Fitzhugh, Kirk
core +1 more source