Results 151 to 160 of about 99,413 (299)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Biological nitrogen fixation in theory, practice, and reality: a perspective on the molybdenum nitrogenase system. [PDF]

FEBS Lett, 2023
Threatt SD, Rees DC.
europepmc   +1 more source

The importance of dissolved organic nutrients in the biogeochemistry of oligotrophic gyres

, 2005
The aim of this thesis is to contribute to the observational database in order to address fundamental questions as to how dissolved organic nutrients influence N and P budgets, how they affect nutrient cycling and the sustainment of biological production
Landolfi, Angela
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Systemic Effects of Nitrate, Asparagine, and Glutamine on Nodulation and Biological Nitrogen Fixation in Soybean. [PDF]

Plants (Basel)
Sun J, Zhao D, Li X, Yang L, Zhao W, Li S, Dong S.   +6 more
europepmc   +1 more source

Isoscapes of remnant and restored Hawaiian montane forests reveal differences in biological nitrogen fixation and carbon inputs. [PDF]

PeerJ, 2023
Wall CB, Swift SOI, D'Antonio CM, Gebauer G, Hynson NA.   +4 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Nickel Supplementation for Enhanced Soybean Growth: A Micrometric-to-Nanometric Investigation of Biological Nitrogen Fixation and Metabolism. [PDF]

ACS Omega
Bezerra de Oliveira J, van der Ent A, Viginotti Alves F, Wurr Rodak B, de Souza Mateus N, Carvalho Mendes NA, Gonçalves JM, Araki K, de Carvalho HWP, Dos Reis AR, Galindo FS, Lavres J.   +11 more
europepmc   +1 more source

Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security? [PDF]

PLoS Biol, 2023
Jhu MY, Oldroyd GED.
europepmc   +1 more source