Results 241 to 250 of about 2,932,261 (286)

Working in biocuration: contemporary experiences and perspectives. [PDF]

Database (Oxford)
Davies SR.
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Enabling pan-repository reanalysis for big data science of public metabolomics data. [PDF]

Nat Commun
El Abiead Y, Strobel M, Payne T, Fahy E, O'Donovan C, Subramamiam S, Vizcaíno JA, Yurekten O, Deleray V, Zuffa S, Xing S, Mannochio-Russo H, Mohanty I, Zhao HN, Caraballo-Rodriguez AM, P Gomes PW, Avalon NE, Northen TR, Bowen BP, Louie KB, Dorrestein PC, Wang M.   +21 more
europepmc   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increased Neuropsychiatric Risk. [PDF]

Biol Psychiatry Glob Open Sci
Moreno-Fernández M, Luján V, Baliyan S, Poza C, Capellán R, de Las Heras-Martínez N, Morcillo MÁ, Oteo M, Ambrosio E, Ucha M, Higuera-Matas A.   +10 more
europepmc   +1 more source

Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data

Advanced Science, EarlyView.
Extended‐field acquisition enables sub‐micron X‐ray imaging of a full mouse brain. The 3.3‐teravoxel volume is reconstructed, registered to a reference atlas, and stored in hierarchical format to augment currently available atlases and improve resolution in the third dimension by an order of magnitude.
Mattia Humbel, Christine Tanner, Marta Girona Alarcón, Georg Schulz, Timm Weitkamp, Mario Scheel, Vartan Kurtcuoglu, Bert Müller, Griffin Rodgers   +8 more
wiley   +1 more source

Addressing standardization and semantics in an electronic lab notebook for multidisciplinary use: LabIMotion. [PDF]

J Cheminform
Lin CL, Huang PC, Wöll C, Théato P, Kübel C, Pilz L, Jung N, Bräse S.   +7 more
europepmc   +1 more source

Autonomous Self‐Evolving Research on Biomedical Data: The DREAM Paradigm

Advanced Science, EarlyView.
DREAM is a fully autonomous, self‐evolving biomedical research system capable of independently formulating scientific questions, performing analyses, and making new discoveries without human intervention. Validated in biomedical studies, DREAM significantly outperforms human scientists in research efficiency, accelerating scientific discovery and ...
Luojia Deng, Yijie Wu, Yongyong Ren, Hui Lu   +3 more
wiley   +1 more source

A multi-objective evolutionary algorithm for detecting protein complexes in PPI networks using gene ontology. [PDF]

Sci Rep
Abbas MN, Broneske D, Saake G.
europepmc   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source