Results 41 to 50 of about 70,455 (289)

The Ontology for Biomedical Investigations.

PLoS ONE, 2016
The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted.
Anita Bandrowski, Ryan Brinkman, Mathias Brochhausen, Matthew H Brush, Bill Bug, Marcus C Chibucos, Kevin Clancy, Mélanie Courtot, Dirk Derom, Michel Dumontier, Liju Fan, Jennifer Fostel, Gilberto Fragoso, Frank Gibson, Alejandra Gonzalez-Beltran, Melissa A Haendel, Yongqun He, Mervi Heiskanen, Tina Hernandez-Boussard, Mark Jensen, Yu Lin, Allyson L Lister, Phillip Lord, James Malone, Elisabetta Manduchi, Monnie McGee, Norman Morrison, James A Overton, Helen Parkinson, Bjoern Peters, Philippe Rocca-Serra, Alan Ruttenberg, Susanna-Assunta Sansone, Richard H Scheuermann, Daniel Schober, Barry Smith, Larisa N Soldatova, Christian J Stoeckert, Chris F Taylor, Carlo Torniai, Jessica A Turner, Randi Vita, Patricia L Whetzel, Jie Zheng   +43 more
doaj   +1 more source

The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration [PDF]

, 2007
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ...
Ashburner, Michael, Bard, Jonathan, Bug, William, Ceusters, Werner, Eilbeck, Karen, Goldberg, Louis J, Ireland, Amelia, Leontis, Neocles, Lewissi, Suzanna, Mungall, Christopher J, OBI Consortium, The, Rocca‐Serra, a b, Rosse, Cornelius, Ruttenberg, Alan, Sansone, Susanna-Assunta, Shah, Migam, Smith, Barry, Whetzel, Patricia L   +17 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dependence relationships between Gene Ontology terms based on TIGR gene product annotations [PDF]

, 2004
The Gene Ontology is an important tool for the representation and processing of information about gene products and functions. It provides controlled vocabularies for the designations of cellular components, molecular functions, and biological processes ...
Borgelt, Christian, Kumar, Anand, Smith, Barry   +2 more
core  

Nanoinformatics: developing new computing applications for nanomedicine [PDF]

, 2012
Nanoinformatics has recently emerged to address the need of computing applications at the nano level. In this regard, the authors have participated in various initiatives to identify its concepts, foundations and challenges.
Alberto Anguita, Alejandro Pazos, Antoine Geissbuhler, B Smith, BY Kim, C Kulikowski, C Rosse, CA Kulikowski, Casimir Kulikowski, Cristian Munteanu, D Dela Iglesia, David Perez-Rey, DG Thomas, Diana De la Iglesia, ED Green, F Martin-Sanchez, Fernando Gonzalez-Nilo, Fernando Martin-Sanchez, Ferran Sanz, George Potamias, Guillermo De la Calle, Guillermo Lopez-Campos, H Berman, IS Kohane, Isabel Hermosilla, Jose Crespo, Jose Maria Barreiro, Josipa Kern, Joyce A. Mitchell, Julio C. Facelli, K Jain, Luciano Milanesi, M Gerstein, M Viceconti, Martin Fritts, Miguel Garcia-Remesal, N Gordon, NA Baker, Nathan Baker, Norbert Graf, P Kiberstis, Paula Otero, Peter Ghazal, Pierre Grangeat, Rada Hussein, Raul E. Cachau, RB Altman, S Bewick, Sabine Koch, SI O’Donoghue, Sonia E. Benitez, V Maojo, V Maojo, V Maojo, V Maojo, Vassilis Moustakis, Victor Maojo, Victoria Lopez-Alonso, Yannick Legre   +58 more
core   +7 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Physical properties of biological entities: an introduction to the ontology of physics for biology. [PDF]

PLoS ONE, 2011
As biomedical investigators strive to integrate data and analyses across spatiotemporal scales and biomedical domains, they have recognized the benefits of formalizing languages and terminologies via computational ontologies.
Daniel L Cook, Fred L Bookstein, John H Gennari   +2 more
doaj   +1 more source

Ontology-based knowledge representation of experiment metadata in biological data mining [PDF]

, 2009
According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone.
Burke, Squires, Carl, Dahlke, Hagler, Herb, Herb, Hagler, Jamie, Lee, Jeff, Wiser, Jennifer, Cai, Karp, David, Megan, Kong, Patrick, Dunn, Richard, Scheuermann, Smith, Barry, Yu, Qian   +12 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The development of non-coding RNA ontology [PDF]

, 2016
Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data ...
Blake, Judith, de Silva, Nisansa, Dou, Deijing, Eilbeck, Karen, Huan, Jun, Huang, Jingshan, Huang, Weili, Jiang, Guoqian, Kasukurthi, Mohan Vamsi, Lin, Yu, Natale, Darren, Ruttenberg, Alan, Smith, Barry, Strachan, Harrison, Wu, Bin, Zimmermann, Michael   +15 more
core   +1 more source