Results 61 to 70 of about 70,455 (289)

Additional Gene Ontology structure for improved biological reasoning [PDF]

Bioinformatics, 2006
Abstract Motivation: The Gene Ontology (GO) is a widely used terminology for gene product characterization in, for example, interpretation of biology underlying microarray experiments. The current GO defines term relationships within each of the independent subontologies: molecular function, biological process and cellular component ...
Simen, Myhre, Henrik, Tveit, Torulf, Mollestad, Astrid, Laegreid   +3 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

MetNetGE: interactive views of biological networks and ontologies

BMC Bioinformatics, 2010
Background Linking high-throughput experimental data with biological networks is a key step for understanding complex biological systems. Currently, visualization tools for large metabolic networks often result in a dense web of connections that is ...
Jia Ming, Choi Suh-Yeon, Reiners Dirk, Wurtele Eve S, Dickerson Julie A   +4 more
doaj   +1 more source

Formal ontology for biomedical knowledge systems integration [PDF]

, 2004
The central hypothesis of the collaboration between Language and Computing (L&C) and the Institute for Formal Ontology and Medical Information Science (IFOMIS) is that the methodology and conceptual rigor of a philosophically inspired formal ontology ...
Fielding, J. M., Simon, J., Smith, Barry
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Creating a new Ontology: a Modular Approach [PDF]

, 2010
Creating a new Ontology: a Modular ApproachComment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on Semantic Web Applications and Tools for the Life Sciences ...
Dmitrieva, Julia, Verbeek, Fons J.
core   +2 more sources

Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD. [PDF]

PLoS ONE, 2011
Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence worldwide. The primary aim of this study was to identify genes and gene ontologies associated with COPD severity.
Santiyagu M Savarimuthu Francis, Jill E Larsen, Sandra J Pavey, Edwina E Duhig, Belinda E Clarke, Rayleen V Bowman, Nick K Hayward, Kwun M Fong, Ian A Yang   +8 more
doaj   +1 more source

Modularization for the Cell Ontology [PDF]

, 2011
One of the premises of the OBO Foundry is that development of an orthogonal set of ontologies will increase domain expert contributions and logical interoperability, and decrease maintenance workload. For these reasons, the Cell Ontology (CL) is being re-
Alexander D. Diehl, Amelia Ireland, Carlo Torniai, Christopher J. Mungall, David Osumi-Sutherland, Melissa A. Haendel, Shahid Manzoor, Terry Meehan   +7 more
core   +2 more sources

Using multiple ontologies to integrate complex biological data

Comparative and Functional Genomics, 2005
AbstractThe strength of the rat as a model organism lies in its utility in pharmacology, biochemistry and physiology research. Data resulting from such studies is difficult to represent in databases and the creation of user‐friendly data mining tools has proved difficult.
Shimoyama, Mary, Petri, Victoria, Pasko, Dean, Bromberg, Susan, Wu, Wenhua, Chen, Jiali, Nenasheva, Nataliya, Kwitek, Anne, Twigger, Simon, Jacob, Howard   +9 more
openaire   +2 more sources