Results 71 to 80 of about 70,455 (289)

The environment ontology: contextualising biological and biomedical entities [PDF]

Journal of Biomedical Semantics, 2013
As biological and biomedical research increasingly reference the environmental context of the biological entities under study, the need for formalisation and standardisation of environment descriptors is growing. The Environment Ontology (ENVO; http://www.environmentontology.org) is a community-led, open project which seeks to provide an ontology for ...
Pier Buttigieg, Norman Morrison, Barry Smith, Christopher J Mungall, Suzanna E Lewis   +4 more
openaire   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The use of concept maps during knowledge elicitation in ontology development processes – the nutrigenomics use case

BMC Bioinformatics, 2006
Background Incorporation of ontologies into annotations has enabled 'semantic integration' of complex data, making explicit the knowledge within a certain field.
Taylor Chris, Stevens Robert, Rocca-Serra Philippe, Castro Alexander, Nashar Karim, Ragan Mark A, Sansone Susanna-Assunta   +6 more
doaj   +1 more source

The BinDiscover database: a biology-focused meta-analysis tool for 156,000 GC–TOF MS metabolome samples

Journal of Cheminformatics, 2023
Metabolomics by gas chromatography/mass spectrometry (GC/MS) provides a standardized and reliable platform for understanding small molecule biology. Since 2005, the West Coast Metabolomics Center at the University of California at Davis has collated GC ...
Parker Ladd Bremer, Gert Wohlgemuth, Oliver Fiehn   +2 more
doaj   +1 more source

An improved ontological representation of dendritic cells as a paradigm for all cell types [PDF]

, 2009
The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the ...
Arighi Cecilia, N., Chris, Mungall, Cowell Lindsay, G., Diehl Alexander, D., Lieberman Anne, E., Maria, Masci Anna, Scheuermann Richard, H., Smith, Barry   +7 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The BSSO Foundry: A community of practice for ontologies in the behavioural and social sciences [version 1; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
There has been a rapid expansion in the quantity and complexity of data, information and knowledge created in the behavioural and social sciences, yet the field is not advancing understanding, practice or policy to the extent that the insights warrant ...
Paulina Schenk, William R. Hogan, Robert West, Björn Gehrke, Janna Hastings, Marta M. Marques, Bruce Chorpita, Harriet M. Baird, Lisa Zhang, Thomas L. Webb, Geert Crombez, Susan Michie, Marie Johnston   +12 more
doaj   +1 more source

Integrating Genomic Knowledge Sources through an Anatomy Ontology [PDF]

, 2004
Modern genomic research has access to a plethora of knowledge sources. Often, it is imperative that researchers combine and integrate knowledge from multiple perspectives.
Gennari, John H, Silberfein, Adam, Wiley, Jesse   +2 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source