Results 81 to 90 of about 70,455 (289)

EL Embeddings: Geometric construction of models for the Description Logic EL ++

, 2019
An embedding is a function that maps entities from one algebraic structure into another while preserving certain characteristics. Embeddings are being used successfully for mapping relational data or text into vector spaces where they can be used for ...
Hoehndorf, Robert, Kulmanov, Maxat, Liu-Wei, Wang, Yan, Yuan   +3 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Integration of multi-scale biosimulation models via light-weight semantics [PDF]

, 2008
Currently, biosimulation researchers use a variety of computational environments and languages to model biological processes. Ideally, researchers should be able to semi- automatically merge models to more effectively build larger, multi-scale models ...
Brian E, Carlson, Daniel L, Cook, John H, Gennari, Maxwell L, Neal   +3 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Using Neural Networks for Relation Extraction from Biomedical Literature

, 2020
Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems.
A Koike, A Lamurias, A Lamurias, A Lamurias, A Lamurias, A Singhal, AV Aho, B Xu, CD Manning, CH Alves, D Westergaard, D Zhou, E Guresen, F Rinaldi, HC Wang, HM Müller, J Hastings, L Aroyo, M Ashburner, MY Kim, N Ma, N Peng, P Goyal, P Zweigenbaum, PN Robinson, Q Li, QL Nguyen, S HayKin, S Hochreiter, TR Gruber, W Wang, WWM Fleuren, Y Hao, Y Luo, Y Xu   +34 more
core   +1 more source

Ontology Engineering Techniques for Biological Data

Journal of Computers, 2014
Now-a-days the challenge that is increasingly being faced in different domains is how to integrate a large amount of available data and information for a particular domain. The purpose of this integration of data is to get an easy understanding of that particular domain.
Asma Fardoos, Jamshaid Iqbal Janjua, Amjad Farooq   +2 more
openaire   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Selected papers from the 15th Annual Bio-Ontologies special interest group meeting [PDF]

, 2013
© 2013 Soldatova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Dumontier, M, Sansone, SA, Shah, NH, Soldatova, LN   +3 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Spatial location and its relevance for terminological inferences in bio-ontologies

BMC Bioinformatics, 2007
Background An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggregation and containment.
Markó Kornél, Schulz Stefan, Hahn Udo
doaj   +1 more source