Results 91 to 100 of about 539,267 (342)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of hydraulic retention time (HRT) in an anaerobic baffled reactor (ABR) on the reduction of BOD and COD in slaughterhouse industrial wastewater [PDF]

Advances in Environmental Technology
The slaughterhouse industry generates large volumes of wastewater with high pollutant levels, such as biological oxygen demand (BOD) and chemical oxygen demand (COD).
Muhammad Al Kholif, Anang Subianto, Joko Sutrisno   +2 more
doaj   +1 more source

Pollution and the State: The Role of the Structure of Government [PDF]

Government spending has significant environmental implications. This paper analyzes the effect of the allocation of government spending between public goods broadly defined and private goods or non-social subsidies on air and water pollution.
Galinato, Gregmar I., Islam, Asif M., Lopez, Ramon E.   +2 more
core   +1 more source

Organic matter remineralization in marine sediments : A Pan-Arctic synthesis [PDF]

, 2017
Natural Environment Research Council (GrantNumber(s): NE/J023094/1; Grant recipient(s): Ursula Witte) ArcticNet (GrantNumber(s): Hotspot biodiversity project; Grant recipient(s): Philippe Archambault)Peer reviewedPublisher ...
Aller, Ambrose, Ambrose, Andersson, Ardyna, Ardyna, Ardyna, Arnosti, Arrigo, Arrigo, Arrigo, Baldwin, Berg, Bergeron, Bianchi, Bidle, Boetius, Boetius, Buesseler, Bélanger, Campbell, Carmack, Carmack, Carroll, Chen, Christensen, Clough, Clough, Darnis, Davenport, Devol, Dittmar, Doxaran, Dunton, Déry, Engelsen, Findlay, Fujiwara, Gaillard, Gaye, Glud, Glud, Glud, Goñi, Goñi, Grant, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Guo, Haine, Harada, Hartnett, Hastie, Hensen, Hill, Hill, Hodal, Hoegh-Guldberg, Hulth, Hulth, Hunt, Jahnke, Jakobsson, Ji, Juul-Pedersen, Jørgensen, Kahru, Kenchington, Kirchman, Kirchman, Klein, Lalande, Le Fouest, Lein, Leu, Li, Link, Link, Link, Lohrer, Lowry, Maslowski, Mathis, McClelland, McKee, McMahon, Michaud, Michaud, Michel, Michel, Michel, Middelburg, Moran, Morata, Morata, Morata, Morison, Na, Nedwell, Olli, Orlova, Pabi, Petrenko, Pfannkuche, Philippe Archambault, Piepenburg, Piepenburg, Piepenburg, Pirtle-Levy, Price, Rachold, Rachold, Reigstad, Renaud, Renaud, Renaud, Rho, Riser, Rowe, Rowe, Roy, Rysgaard, Rysgaard, Rysgaard, Sakshaug, Sampei, Sampei, Sauter, Sauter, Schewe, Schewe, Schmid, Schuur, Seiler, Serreze, Solan, Soltwedel, Soltwedel, Solveig Bourgeois, Stief, Stroeve, Suess, Sun, Sun, Søreide, Søreide, Tamelander, Tank, Thamdrup, Tremblay, Tremblay, Ursula Witte, Wakeham, Wassmann, Welch, Wexels Riser, Witte, Wollenburg, Wollenburg, Woodgate, Yang, Zabel   +166 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Assessing the freshwater quality of a large-scale mining watershed : the need for integrated approaches [PDF]

, 2019
Water quality assessments provide essential information for protecting aquatic habitats and stakeholders downstream of mining sites. Moreover, mining companies must comply with environmental quality standards and include public participation in water ...
Arroyo, Nilton Deza, Beeckman, Eveline, De Saeyer, Nancy, De Schamphelaere, Karel, Forio, Marie Anne Eurie, Goethals, Peter, Mercado Garcia, Daniel, Sanchez Peña, Marco, Van Buggenhoudt, Cécile, Van Butsel, Jana, Wyseure, Guido   +10 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Degradasi Bod Dan Cod Pada Sistem Lumpur Aktif Pengolahan Limbah Cair Tekstil [PDF]

, 2007
Observation of waste parameter in textile wastewater treatment wasdone. This experimental investigation consist of three mayor textileparameter including total suspended solid (TSS), biological oxygendemand (BOD) and chemical oxygen demand (COD).
Komarawidjaja, W. (Wage)
core  

Rheological characterization of mixed liquor in a submerged membrane bioreactor: Interest for process management [PDF]

, 2008
Rheological analyses of a submerged membrane bioreactor mixed liquor were performed in the aim of characterizing the mixed liquor present in the bioreactor and thus proposing a process management.
Albasi, Claire, Alliet-Gaubert, Marion, Anne-Archard, Dominique, Van Kaam, Romuald   +3 more
core   +1 more source