Results 101 to 110 of about 539,267 (342)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

WATER POLLUTION LEVELS IN THE SUWUNG ESTUARY, BALI, BASED ON BIOLOGICAL OXYGEN DEMAND

Biotropia: The Southeast Asian Journal of Tropical Biology, 2018
Biological Oxygen Demand (BOD) is generally used for determining water pollution levels in bodies of water. Estuary is a semi-enclosed body of water that can be polluted via land areas or rivers.
Ni Luh Gede Rai Ayu Saraswati, I Wayan Arthana, I Gede Surya Risuana, I Gede Hendrawan   +3 more
doaj   +1 more source

Water quality studies of Hoskerehalli lake of Bangalore, Karnataka [PDF]

, 2010
The aim of the current study was to evaluate the status of the Hoskerehalli lake water with respect to different physicochemical parameters [pH, temperature, total dissolved solids (TDS), turbidity, electrical conductivity (EC), total hardness (TH ...
Latha, N., Ramachandra Mohan, M.
core  

An evaluation of metal removal during wastewater treatment: The potential to achieve more stringent final effluent standards [PDF]

, 2011
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 Taylor & Francis.Metals are of particular importance in relation to water quality, and concern regarding the impact of these ...
Arundel J., Barnes D., Barth E. F., Birkett J. W., Brown H. G., Chen K. Y., Cheng M. H., D. Ziolko, Davis J. A., Eckenfelder W. W., Esmond S. E., Fatoki O. S., Gray N. F., Groombridge B., Hawksworth D. L., Henson M. C., J. N. Lester, Klein L. A., Koch C. M., Koch M., Landner L., Landner L., Lawson P. S., Le Quesne T., Lester J. N., Lester J. N., Lester J. N., Lester J. N., Lester J. N., Liu Y., M. D. Scrimshaw, Malaney G. W., Mowat A., Neufeld R. D., Neufeld R. D., O. V. Martin, Raposo J. C., Reid W., Roberts P., Rossin A. C., Rudd T., Rule K. L., Spath R., Stander L., Stasinakis A. S., Stonebrook H., Stover R. C., Takiguchi M., Tomlinson T. G., Verma M. M., Yeoman S.   +50 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Efektifitas Filter Batang Pisang terhadap Penurunan Kadar Total Suspended Solid, Chemical Oxygen Demand dan Biological Oxygen Demand pada Limbah Domestik

, 2021
Emi Jayanti Dwi Pratiwi, Eko Sulistiono, Mimatun Nasihah   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Integrating vocational training in culinary arts and Islamic studies at juvenile rehabilitation centres: Malaysian experience [PDF]

, 2017
The Juvenile Rehabilitation Centres (JRC) in Malaysia aims to provide shelter, counselling and skills training to juveniles specifically for those who wish to transform themselves from the regrettable misdeeds they have committed.
Abd. Aziz, Z. S.A.A., Esa, Ahmad, Mohamad,, N. H., Mohd Salleh, B.   +3 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Total Maximum Daily Load Application Using Biological Oxygen Demand, Chemical Oxygen Demand, and Ammoniacal Nitrogen: A Case Study for Water Quality Assessment in the Perai River Basin, Malaysia [PDF]

, 2023
Siti Multazimah Mohamad Faudzi, Danial Nakhaie Mohd Souhkri, Muhammad Fitri Mohd Akhir, Hamidi Abdul Aziz, Muhammad Zaki Mohd Kasim, Nor Azazi Zakaria, Noor Aida Saad   +6 more
openalex   +1 more source